Mina's Page




Bissell Lab Publications : 1971-2015

The investigations are currently being supported by grants and a Distinguished Fellowship Award from the U.S. Department of Energy, Office of Biological and Environmental Research (DE-AC03 SF0098), by an Innovator Award from the Department of Defense Breast Cancer Research Program (DAMD170210438) to M.J. Bissell, by the National Cancer Institute (CA64786 to M.J.B.; CA57621 to Zena Werb and M.J.B.) and a Department of Defense Breast Cancer Research Program grant (BC044087).

1970-1994, 1995, 1996, 1997, 1998, 1999, 2000, 2001, 2002, 2003, 2004,2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015

* Last updated 03.01.2016

Welcome to our archive. Here we are making available pdf reprints of as many articles as journal copyrights will permit us, including old articles which may be difficult for interested readers to find. Active links lead to the article abstract on PubMed. Those indicated *pdf* are lead directly to a downloadable pdf. Unlinked citations mean that the journal publishers do not permit authors to archive reprints on their personal not-for-profit web pages, or that a pdf image of that paper is unavailable. We hope to generate pdfs of some of our more important earlier publications and archive these here in the future.




  • Diamond MI, Cai S, Boudreau A, Carey CJ Jr, Lyle N, Pappu RV, Swamidass SJ, Bissell M, Piwnica-Worms H, Shao J. (2015) Subcellular localization and ser-137 phosphorylation regulate tumor suppressive activity of profilin-1. J Biol Chem. 2015 Feb 13. pii: jbc.M114.619874. [Epub ahead of print]PMID:25681442
  • Zhang P, Lo A, Huang Y, Huang G, Liang G, Mott J, Karpen GH, Blakely EA, Bissell MJ, Barcellos-Hoff MH, Snijders AM, Mao JH. (2015) Identification of genetic loci that control mammary tumor susceptibility through the host microenvironment. Science Report. 2015 Mar 9;5:8919. doi: 10.1038/srep08919. PMID: 25747469
  • Inman JL, Robertson C, Mott JD, Bissell MJ. (2015) Mammary gland development: cell fate specification, stem cells and the microenvironment. Development. 2015 Mar 15;142(6):1028-1042. PMID:25758218
  • Gomes AM, Bhat R, Correia AL, Mott JD, Ilan N, Vlodavsky I, Pav„o MS, Bissell M. (2015) Mammary branching morphogenesis requires reciprocal signaling by heparanase and MMP-14. J Cell Biochem. 2015 Mar 3. doi: 10.1002/jcb.25127. [Epub ahead of print] PMID:2573587
  • Hines, W.C., Yaswen, P. & Bissell, M.J. (2015) Modelling breast cancer requires identification and correction of a critical cell lineage-dependent transduction bias. Nature communications 6, 6927 Hoshuni, A., Costa-Silva, B., Davies, A., Bissell, MJ, Lyden, D. (2015) Tumour exosome organotropic metastasis., Nature., Sept 2015


  • Hines WC, Su Y, Kuhn I, Polyak K and Bissell M (2014). Sorting out the FACS: A devil in the details. Cell Reports. 2014 Mar 13. doi: 10.1016/j.celrep.2014.02.021.
  • Bhat R and Bissell MJ (2014) Of plasticity and specificity: dialectics of the micro- and macro-environment and the organ phenotype. Wiley Interdiscip Rev Dev Biol. 2014 Mar-Apr;3(2):147-63. doi: 10.1002/wdev.130. Epub 2013 Nov 18.
  • Veiseh M, Kwon DH, Borowsky AD, Tolg C, Leong HS, Lewis JD, Turley EA, Bissell MJ. (2014) Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1731-9. doi: 10.1073/pnas.1402383111. Epub 2014 Apr 14.
  • Snijders AM, Langley S, Mao JH, Bhatnagar S, Bjornstad KA, Rosen CJ, Lo A, Huang Y, Blakely EA, Karpen GH, Bissell MJ, Wyrobek AJ. (2014) An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival. Oncotarget. 2014 Jun 30;5(12):4011-25
  • Chuong CM, Bhat R, Widelitz RB, Bissell MJ (2014) SnapShot: Branching Morphogenesis. (2014) Cell. 2014 Aug 28;158(5):1212-1212.e1. doi: 10.1016/j.cell.2014.08.019
  • NisticÚ P, Di Modugno F, Spada S, Bissell MJ. (2014) ?1 and ?4 integrins: from breast development to clinical practice. Breast Cancer Res. 2014;16(5):459.PMID:25606594[PubMed - in process]
  • Mroue R, Inman J, Mott J, Budunova I, Bissell MJ. (2014) Asymmetric expression of connexins between luminal epithelial and myoepithelial cells is essential for contractilefunction of the mammary gland. Dev Biol. 2014 Dec 11. pii: S0012-1606(14)00614-9. doi: 10.1016/j.ydbio.2014.11.026. [Epub ahead of print] PMID 25500615


  • Strachan D, Ruffell B, Oei Y, Bissell MJ, Coussens L, Pryer N, and Daniel D (2013). 1CSF1R inhibition delays tumor growth in cervical and mammary transgenic mouse models by preventing turnover of tumor-associated macrophages and enhancing infilitration of CD8+ T cells. OncoImmunology. 2013 Dec 1. doi: 10.4161/onci.26968
  • Onodera Y, Nam JM and Bissell MJ (2013). Increased sugar uptake and metabolism lead to oncogenic activation via EPAC-Rap1 and O-GlcNAc pathways . J Clin Invest. 2013 Dec 9. doi:pii: 63146. 10.1172/JCI63146.
  • Bhat R and Bissell MJ (2013). Of plasticity and specificity: dialectics of the microenvironment and macroenvironment and the organ phenotype. WIREsDev Biol 2013.doi:10.1002/wdev.130.
  • Bissell MJ (2013). Reproducibility: The risks of the replication drive. Nature 21 November 2013 Vol 503, 333-334.
  • Becker-Weimann S, Xiong G, Furuta S, Han J, Kuhn I, Akavia UD, Pe'er D, Bissell MJ and Xu R (2013). NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals. Oncotarget. 2013 Oct 14.
  • Boudreau A, Tanner K, Wang D, Geyer FC, Reis-Filho JS, and Bissell MJ (2013). 14-3-3σ stabilizes a complex of soluble actin and intermediate filament to enable breast tumor invasion. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):E3937-44. doi: 10.1073/pnas.1315022110. Epub 2013 Sep 25.
  • Bascom JL, Radisky DC, Koh E, Fata JE, Lo A, Roosta N, Hirai Y,and Bissell MJ (2013). Epimorphin is a novel regulator of the progesterone receptor isoform-A. Cancer Research. July 18. doi: 10.1158/0008-5472.CAN-13-0021
  • Ghajar CM, Peinado H, Mori H, Matei IR, Evanson KJ, Brazier H, Almeida D, Koller A, Hajjar KA, Stainer D, Chen EI, Lyden D and Bissell MJ (2013). The perivascular niche regulates breast tumor dormancy. Nature Cell Biology. 2013 June 2. doi: 10.1038/ncb2767.
  • Correia AL, Mori H, Chen EI, Schmitt FC and Bissell MJ (2013). The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90β. Genes Development. 2013 April. 1: 27(7): 8105-17. doi:0.1101/gad.211383.112.
  • Brownfield DG, Venugopalan G, Lo A, Mori H, Tanner K, Fletcher DA, Bissell MJ (2013). Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules. Current Biology. 2013 April 2. doi:pii: S0960-9822(13)00334-5.10.1016/j.cub.2013.03.032.
  • Lee SE, Alivastos AP, and Bissell MJ (2013). Towards plasmonics-enabled spatiotemporal activity patterns in three-dimensional culture models. Systems Biomedicine. 1:1, 1-8; March 2013.
  • Mori H, Lo AT, Ghajar CM, Inman JL, Alcaraz J, Chen CS, Nelson CM, Zhang H, Mott JD, Bascom JL, Seiki M, and Bissell MJ (2013). Transmembrane/ cytoplasmic, rather than catalytic, domains of Mmp 14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1. Development. 2013 January: 140(2): 343-52. doi:10.1242/dev.084236.
  • Mroue R,Bissell MJ (2013). Three-dimensional cultures of mouse mammary epithelial cells. Methods Molecular Biology. 2013; 945: 221-50. doi: 10.1007/978-1-62703-125-7_14
  • Vidi PA, Bissell MJ, Lelievre SA (2013). Three-dimensional culture of human breast epithelial cells: The how and why. Methods Molecular Biology. 2013; 945: 193-219. doi: 10.1007/978-1-62703-125-7_13.



  • Mroue R,Bissell MJ (2013). Three-dimensional cultures of mouse mammary epithelial cells. Methods Molecular Biology. 2013; 945: 221-50. doi: 10.1007/978-1-62703-125-7_14
  • Vidi PA, Bissell MJ, Lelievre SA (2013). Three-dimensional culture of human breast epithelial cells: The how and why. Methods Molecular Biology. 2013; 945: 193-219. doi: 10.1007/978-1-62703-125-7_13.
  • Ordinario E, Han HJ, Furuta S, Heiser LM, Jakkula LR, Rodier F, Spellman PT, Campisi J, Gray JW, Bissell MJ, Kohwi Y and Khowi-Shigematsu T (2012). ATM suppresses SATB1- induced malignant progression in breast epithelial cells. PLos One. 2012 Decmber 10; 7(12).
  • Di Modungo F, Iapicca P, Boudreau A, Mottolese M, Terrenato I, Perracchio L, Carstens RP, Santoni A, Bissell MJ, Nistico P (2012). Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal- like breast tumors. Proceedings of the National Academy of Science. 2012 November 5.
  • Ashton RS, Conway A, Pangarkar C, Bergen J, Lim KI, Shah P, Bissell MJ, Schaffer DV. Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling. Nature Neuroscience. October 2012; 15(10): 1399-406.
  • Lee SY, Meier R, Furuta S, Lenburg ME, Kenny PC, Xu R and Bissell MJ (2012). Identification and characterization of FAM83A, a clinically-relevant cancer-associated gene which interacts with c-RAF and P13K, and confers EGFR-TKI resistance in breast cancer cells. Journal of Clinical Investigation. August 13 2012.
  • Boudreau A, van't Veer LJ and Bissell MJ (2012). An "elite hacker" breast tumors exploit the normal microenvironment program to intsruct their progression and biological diversity. Cell Adhesion and Migration. June 2012; 6(3): 1-13.
  • Jahchan NS, Wang D, Bissell MJ, Luo K (2012). SnoN regulates mammary gland alveologenesis and onset of lactation by promoting prolactin/Stat5 signaling. Development. 2012 July 25.
  • Lee SE, Sasaki DY, Park Y, Xu R, Brennan JS,Bissell MJ, Lee LP (2012). Photonic gene circuits by optically addressable siRNA-Au nanoantennas. ACS Nanotechnology. 2012 July 24.
  • Meier R, Radisky DC and Bissell MJ (2012). The importance of the microenvironment in cancer induction and progression. In: Cancer The Outlaw Cell. Richard E. LaFond ed. Oxford University Press. London New York.
  • Liu H, Radisky DC, Yang D, Xu R, Radisky ES, Bissell MJ*, Bishop MJ* (2012). MYC Can Supress Human Cancer Cell Metastasis by Direct Transcriptional Silencing of αV β3 Integrin Subunits. Nat Cell Biol. 2012 May 13. *Both senior authors contributed equally.
  • Lo AT, Mori H, Mott J, Bissell MJ (2012). Constructing Three-Dimensional Models to Study Mammary Gland Branching Morphogenesis and Functional Differentiation. J Mammary Gland Biol Neoplasia. 2012 May 10.
  • Mori H, Borowsky AD, Bhat R, Ghajar CM, Seiki M and Bissell MJ (2012). LS-TAFI, a new technique for analysis of microanatomy in whole mount tissues. Am J Pathol. 2012 Apr 26.
  • Nakasone ES, Askautrud HA, Kees T, Park JH, Plaks V, Ewald AJ, Fein M, Rasch MG, Tan YX, Qiu J, Park J, Sinha P, Bissell MJ, Frengen E, Werb Z, Egeblad M (2012). Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell. 2012 Apr 17; 21(4):488-503.
  • Dusek RL, Bascom JL, Vogel H, Baron S, Borowsky AD, Bissell MJ, Attardi LD (2012). Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer. Breast Cancer Res. 2012 Apr 20;14(2):R65.
  • Kim J, Villadsen R, Sørlie T, Fogha L, Grønlund SZ, Fridriksdottir AJ, Kuhn I, Rank F, Wieleng VT, Solvang H, Edwards PAW, Børresen-Dale AL, Rønnov-Jessen L, Bissell MJ*, Petersen OW* (2012). Tumor initiating but differntiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity. Proc Natl Acad Sci USA. 2012 Apr 17;109(16):6124-9. *Both senior authors contributed equally.
  • Bissell MJ, Ghajar CM, Lee LP (2012). From single cells to biology. Integr Biol (Camb). 2012 Mar 21.
  • Correia AL and Bissell MJ (2012). The tumor microenvironment is a dominant force in multidrug resistance. Drug Resistance Updates. Drug Resist Updat. 2012 Feb 13.
  • Vidi PA, Chandramouly G, Gray M, Wang L, Liu E, Kim JJ, Roukos V, Bissell MJ, Moghe PV, Lelievre SA (2012). Interconnected Contribution of Tissue Morphogenesis and teh Nuclear Protein NuMA to the DAN Damge Response. Journal of Cell Science. JCell Sci. 2012 Jan 15;125(Pt 2):350-61. Epub 2012 Feb 13.
  • Tanner K, Mori H, Mroue R, Bruni-Cardoso A, and Bissell MJ (2012). Coherent angular motion in the establishment of multicellular architecture of glandular tissues. Proc Natl Acad Sci USA. 2012 Jan 25.
  • Nistico P, Bissell MJ and Radisky D (2012). Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases. Cold Spring Harb Prespect Biol. 2012 Feb 1;4(2).
  • Freed-Poastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polots kaia A, Bissell MJ, Osborne TF, Tian B, Lowe SW, Silva JM, Børresen-Dale AL, Levine AJ, Bargonetti J and Prives C (2012). Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway. Cell. 2012 Jan 20;148(1-2):244-58.
  • Neumaier T, Swenson J, Pham C, Polyzos A, Lo AT, Yang P, Dyball J, Asaithamby A, Chen DJ, Bissell MJ, Thalhammer S and Costes S (2012). Evidence for formation of DNA repair centers and dose-response non-linearity in human cells. Proc Natl Acad Sci USA. 2012 Jan 10;109(2):443-8
  • Bissell MJ (2011). Heeding a mentor's advice: A lesson in presistence. Nature Cell Biology. 2011 Dec; 13(12).
  • Veiseh M, Breadner D, Ma J, Akentieva N, Savani RC, Harrison RE, Mikilus D, Collis L, Gustafson S, Lee TY, Koropatnick J, Luyt LG, Bissell MJ, Turley EA (2011). Imaging of homeostatic, neoplastic and injured tissues by HA-based probes. Biomacromolecules. 2011 Nov 9.
  • Inman JL, Mott JD and Bissell MJ (2011). The extracellular matrix as a multivalent signaling scaffold that orchestrates tissue organization and function. Tumor-associated Fibroblasts and their Matrix. Prof. Dr. Margareta M. Mueller and Dr. Norbert E. Fuesnig eds. pp. 285-300. Springer Dordrech Heidelberg London New York.
  • Furuta S, Ghajar CM and Bissell MJ (2011). Caveolin-1: Would-be Achilles' heel of tumor microenvironment? Cell Cycle. 2011 Oct 31;10(20).
  • Alcaraz J, Mori H, Ghajar CM, Brownfield D, Galgoczy R and Bissell MJ (2011). Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening. Integr Biol. 2011 Oct 13. (cover highlight).
  • Pontiggia O, Sampayo R, Raffo D, Motter A, Xu R, Bissell MJ, Joffe EB, Simian M (2011). The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for souble factors and fibronectin through β1-integrin
  • Huang C, Park CC, Hilsenbeck SG, Ward R, Rimawi M, Wang YC, Shou J, Bissell MJ, Osborne, CK, Schiff R (2011). β1-integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib. Breast Cancer Res. 2011 Aug 31;13(4):R84
  • Bissell MJ, Rosen JM and Polyak K (2011). Cold Spring Harbor Perspectives in Biology. The Mammary Gland as an Experimental Model. Cold Spring Harbor Laboratory Press.
  • Furuta S, Jeng YM, Zhou L, Huang L, Kuhn I, Bissell MJ, Lee WH (2011). IL-25 Causes Apoptosis of IL-25R-Expressing Breast Cancer Cells Without Toxicity to Nonmalignant Cells. Sci Transl Med
  • Spencer VA, Costes S, Inman JL, Xu R, Chen J, Hendzel MJ and Bissell MJ (2011) Depletion of Nuclear Actin is a Key Mediator of Quiescence in Epithelial Cells. JCS.
  • Chanson L, Brownfield D, Garbe JC, Kuhn I, Stampfer MR, Bissell MJ, Labarge MA (2011) Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells. PNAS.
  • Bissell MJ and Hines C (2011) Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nature Medicine
  • Bissell MJ (2010). Cell Biology: A Love Affair. ASCB 50th Anniversary Essay. Molecular Biology of the Cell.
  • Beliveau A, Mott JD, Lo A, Chen EI, Koller AA, Yaswen P, Muschler J and Bissell MJ (2010). Raf-induced MMP9 Disrupts Tissue Architecture of Human Breast Cells in Three-Dimensional Culture and is Necessary for TUmor Growth in vivo. Genes and Development.
  • Andersen K, Mori H, Fata J, Oyjord T, Maelandsmo GM, Bissell MJ (2010). The metastatsis-promoting protein S100A4 regulates mammary branching morphogenesis. Developmental Biology.
  • Inman JL and Bissell MJ (2010). Apical polarity in three-dimensional culture systems: where to now? J Biol. 2010 Jan 21;9(1):2
  • Spencer VA, Xu R, Bissell MJ (2010). Gene Expression in the Third Dimension: The ECM-nucleus Connection. J Mammary Gland Biol Neoplasia. 2010 Mar; 15(1):65-71.
  • Han J, Chang H, Giricz O, Lee GY, Bachner FL, Gray JW, Bissell MJ, Kenny PA, and Parvin B (2010). Molecular Predictors of 3D Morphogenesis by Breast Cancer Cell Lines in 3D Culture. PLoS Comput Biol. 2010 February; 6(2)
  • Ghajar CM and Bissell MJ (2010). Tumor engineering: the other face of tissue engineering. Tissue Enginerring: Part A. 2010 Apr 14.
  • Nam JM, Onodera Y, Bissell MJ, Park CC (2010). Breast Cancer Cells in Three-dimensional Culture Display an Enhanced Radioresponse after Coordinate Targeting of Integrin {alpha}5{beta}1 and Fibronectin. Cancer Res. 2010 Jun 1.
  • Xu R, Spencer VA, Groesser DL and Bissell MJ (2010) Laminin regulates PI3K basal localization and activation to sustain STAT5 activation. Cell Cycle. 2010 Nov; 9(21):4315-22.
  • Tanner K, Boudreau A, Bissell MJ and Kumar S (2010) Dissecting regional variations in stress fiber mechanics in living cells with laser nanosurgery. Biophys J. 99(9):2775-83.


  • Simian M, Bissell MJ, Barcellos-Hoff MH, Shyamala G (2009). Estrogen and progesterone receptors have distinct roles in the establishment of the hyperplastic phenotype in PR-A transgenic mice. Breast Cancer Research 2009, 11:R72 (29 September 2009)
  • Mori H, Gjorevskib N, Inman JL, Bissell MJ and Nelson CM (2009). Self-organization of engineered epithelial tubules by differential cellular motility. PNAS. Proc Natl Acad Sci U S A. 2009 Aug 18.
  • Weigelt B, Lo AT, Park CC, Gray JW and Bissell MJ (2009). HER2 signaling pathway activation and response of breast cancer cells to HER2 targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res Treat. Breast Cancer Res Treat. 2009 Aug 22.
  • Chen A, Cuevas I, Kenny PA, Miyake H, Mace K, Ghajar C, Boudreau A, Bissell MJ and Boudreau, N (2009). Endothelial Cell Migration and VEGF Expression are the result of Loss of Breast Tissue Polarity. Cancer Res. 2009 69: 6721-6729.
  • Ghajar CM, Meier R and Bissell MJ (2009). Quis custodiet ipsos custodies: who watches the watchmen? Am J Pathol. 2009 Jun; 174(6):1996-9.
  • Fournier MV, Fata JE, Martin KJ, Yaswen P, Bissell MJ (2009). Interaction of E-cadherin and PTEN Regulates Morphogenesis and Growth Arrest in Human Mammary Epithelial Cells. Cancer Res. 2009 May 5.
  • Zhang X, Fournier MV, Ware JL, Bissell MJ, Yacoub A and Zehner ZE (2009). Inhibition of vimentin or b1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo. Mol Cancer Ther. 2009 Mar 1; 8(3):499–508.
  • Radisky DC, Stallings-Mann M, Hirai Y and Bissell MJ (2009). Single proteins might have dual but related functions in intracellular and extracellular microenvironments. Nat Rev Mol Cell Biol. 2009 Mar; 10(3):228–34.
  • Xu R, Boudreau A and Bissell MJ (2009). Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices. Cancer Metastasis Rev. 2009 Jun; 28(1-2):167–76.
  • Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek AJ, Bissell MJ, McCormick F, Kuo WL, Mills GB, Gray JW and Korn WM (2009). Basal-subtype and (MAPK)/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009 Jan 15; 69(2):565–72.
  • Xu R, Nelson CM, Muschler JL, Veiseh M, Vonderhaar BK and Bissell MJ (2009). Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. J Cell Biol. 2009 Jan 12; 184(1):57–66.
  • Chen CS, Nelson CM, Khauv D, Bennett S, Radisky ES, Hirai Y, Bissell MJ and Radisky DC (2009). Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. J Biol Chem. 2009 Mar 13; 284(11):6877–84.
  • Rønnov-Jessen L and Bissell MJ (2009). Breast cancer by proxy: can the microenvironment be both the cause and consequence? Trends Mol Med. 2009 Jan; 15(1):5–13.
  • LaBarge MA, Nelson CM, Villadsen R, Fridriksdottir A, Ruth JR, Stampfer M, Petersen OW and Bissell MJ (2009). Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr Biol. 2009 Jan; 1:70–9.


  • Ghajar CM and Bissell MJ (2008). Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging. Histochem Cell Biol. 2008 Dec; 130(6):1105–18.
  • Alcaraz J, Xu R, Mori H, Nelson CM, Mroue R, Spencer VA, Brownfield D, Radisky DC, Bustamante C and Bissell MJ (2008). Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J. 2008 Nov 5; 27(21):2829–38.
  • Bissell MJ and Inman J (2008). Reprogramming stem cells is a microenvironmental task. Proc Natl Acad Sci USA. 2008 Oct 14; 105(41):15637–8.
  • Martin KJ, Patrick DR, Bissell MJ and Fournier MV (2008). Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets. PLoS ONE. 2008 Aug 20; 3(8):e2994.
  • Veiseh M, Turley EA and Bissell MJ (2008). A top-down analysis of a dynamic environment: extracellular matrix structure and function. In: Laurencin C and Nair L, eds., Nanotechnology and Tissue Engineering: The Scaffold, pp. 33-51. Boca Raton, FL: CRC Press/Taylor and Francis Group.
  • Park CC, Zhang HJ, Yao ES, Park CJ and Bissell MJ (2008). b1 integrin inhibition dramatically enhances radiotherapy efficacy. Cancer Res. 2008 Jun 1; 68(11):4398-405.
  • Nelson CM, Khauv D, Bissell MJ and Radisky DC (2008). Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J Cell Biochem. 2008 May 27 (cover feature).
  • Labarge MA and Bissell MJ (2008). Is CD133 a marker of metastatic colon cancer stem cells? J Clin Invest. 2008 Jun 2; 118(6):2021-4.
  • Weigelt B and Bissell MJ (2008). Unraveling the microenvironmental influences on the normal mammary gland and induction and progression of breast cancer. Semin Cancer Biol. 2008 Mar 26.
  • Hu M, Yao J, Carroll DK, Weremowicz S, Chen H, Carrasco D, Richardson A, Violette S, Nikolskaya T, Nikolsky Y, Bauerlein EL, Hahn WC, Gelman RS, Allred C, Bissell MJ, Schnitt S and Polyak K (2008). Regulation of in situ to invasive breast carcinoma transition. Cancer Cell. 2008 May; 13(5):394-406 (cover feature).
  • Triffo WJ, Palsdottir H, McDonald KL, Lee JK, Inman JL, Bissell MJ, Raphael RM and Auer M (2008). Controlled microaspiration for high-pressure freezing: a new method for ultrastructural preservation of fragile and sparse tissues for TEM and electron tomography. J Microscopy. 2008 May; 230(2):278-87.
  • Nelson CM, Inman JL and Bissell MJ (2008). Three-dimensional lithographically-defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression. Nat Protoc. 2008; 3(4):674-8.
  • Turley EA, Veiseh M, Radisky DC and Bissell MJ (2008). Mechanisms of disease: epithelial–mesenchymal transition and back again: does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol. 2008 May; 5(5):280-90.
  • Faddy HM, Smart CE, Xu R, Lee GY, Kenny PA, Feng M, Rao R, Brown MA, Bissell MJ, Roberts-Thomson SJ and Monteith GR (2008). Localization of plasma membrane and secretory calcium pumps in the mammary gland. Biochem Biophys Res Comm. 2008 May 9; 369(3):977–81.
  • Rizki A, Weaver VM, Lee SY, Rozenberg GI, Chin K, Myers CA, Bascom JL, Mott JD, Semeiks JR, Grate LR, Mian IS, Borowsky AD, Jensen RA, Idowu MO, Chen F, Chen DJ, Petersen OW, Gray JW and Bissell MJ (2008). A human breast cell model of preinvasive to invasive transition. Cancer Res. 2008 Mar 1; 68(5):1378–87 (cover feature).


  • Rizki A, Mott JD, and Bissell MJ (2007). Polo-like kinase 1 is involved in breast cancer cell invasion through extracellular matrix. Cancer Res. 2007 Dec 1; 67(23):11106-10.
  • Bissell MJ (2007). Architecture is the message: the role of extracellular matrix and 3-D structure in tissue-specific gene expression and breast cancer. The Pezcoller Foundation Journal. 2007 Nov; 29:2-17.
  • Andarawewa KL, Erickson AC, Chou WS, Costes SV, Gascard P, Mott JD, Bissell MJ and Barcellos-Hoff MH (2007). Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res. 2007 Sep 15; 67(18):8662-70.
  • LeBeyec J, Xu R, Lee SY, Nelson CM, Rizki A, Alcaraz J and Bissell MJ (2007). Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp Cell Res. 2007 Aug 15; 313:3066-75.
  • Radisky DC, Kenny PA and Bissell MJ (2007). Fibrosis and cancer: do myofibroblasts come from epithelial cells via EMT? J Cell Biochem. 2007 Jul 1; 101(4):830-9.
  • Hamilton SR, Fard SF, Paiwand FF, Tolg C, Veiseh M, Wang C, McCarthy JB, Bissell MJ, Koropatnick J and Turley EA (2007). The hyaluronan receptors CD44 and RHAMM (CD168) form complexes with ERK1,2, which sustain high basal motility in breast cancer cells. J Biol Chem. 2007 Jun 1; 282(22):16667-80.
  • Fata JE, Mori H, Ewald AJ, Zhang H, Yao E, Werb Z and Bissell MJ (2007). The MAPKERK-1,2 pathway integrates distinct and antagonistic signals from TGFb and FGF7 in morphogenesis of mouse mammary epithelium. Dev Biol. 2007 Jun 1; 306(1):193-207.
  • Xu R, Spencer VA and Bissell MJ (2007). Extracellular matrix-regulated gene expression requires cooperation of SWI SWI/SNF and transcription factors. J Biol Chem. 2007 May 18; 282(20):14992-9.
  • Itoh M, Nelson CM, Myers CA and Bissell MJ (2007). Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. Cancer Res. 2007 May 15; 67(10):4759-66 (cover feature).
  • Kenny PA, Lee GY and Bissell MJ (2007). Targeting the tumor microenvironment. Front Biosci. 2007 May 1; 12:3468-74.
  • Sandal T, Valyinagy K, Spencer VA, Folberg R, Bissell MJ and Maniotis AJ (2007). Epigenetic reversion of breast carcinoma phenotype is accompanied by changes in DNA sequestration as measured by AluI restriction enzyme. Am J Pathol. 2007 May; 170(5):1739-49 (cover feature).
  • Villadsen R, Fridriksdottir AJ, Rønnov-Jessen L, Gudjonsson T, Rank F, Labarge MA, Bissell MJ and Petersen OW (2007). Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol. 2007 Apr 9; 177(1):87-101.
  • Radisky DC and Bissell MJ (2007). NF-kappaB links oestrogen receptor signalling and EMT. Nat Cell Biol. 2007 Apr; 9(4):361-3.
  • Lee GY, Kenny PA, Lee EH, and Bissell MJ (2007). Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods. 2007 Apr; 4(4):359-65.
  • Beliveau A, Bassett E, Lo AT, Garbe J, Rubio MA, Bissell MJ, Campisi J and Yaswen P (2007). p53-dependent integration of telomere and growth factor deprivation signals. Proc Natl Acad Sci USA. 2007 Mar 13; 104(11):4431-6.
  • Kenny PA and Bissell MJ (2007). Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest. 2007 Feb; 117(2):337-45
  • Bissell MJ (2007). Modelling molecular mechanisms of breast cancer and invasion: lessons from the normal gland. Biochem Soc Trans. 2007 Feb; 235(Pt 1):18-22.
  • Spencer VA, Xu R and Bissell MJ (2007). Extracellular matrix, nuclear and chromatin structure and gene expression in normal tissues and malignant tumors: a work in progress. Adv Cancer Res. 2007; 97:275-94.
  • Labarge MA, Petersen OW and Bissell MJ (2007). Culturing mammary stem cells. In: Freshney IR, Stacey GN & Auerback JM, eds., Culture of Human Stem Cells. Hoboken: John Wiley & Sons.
  • Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, Lorenz K, Lee EH, Barcellos-Hoff MH, Petersen OW, Gray JW and Bissell MJ. The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Molecular Oncology. 2007;1(1):84-96.
  • Radisky DC, Kenny PA, Bissell MJ. Fibrosis and Cancer: Do myofibroblasts come from epithelial cells via EMT? Journal of Cellular Biochemistry. 2007 Jan 8.


  • Myers C, Liu H, Lee E, and Bissell MJ.Three-Dimensional Cultures of Normal and Malignant Human Breast Epithelial Cells to Achieve in vivo-like Architecture and Function. In Cell Biology: A Laboratory Handbook, 2006;Third Edition, Julio Celis, Editor.
  • Park CC, Zhang H, Pallavicini M, Gray JW, Baehner F, Park CJ, Bissell MJ. ß1 Integrin Inhibitory Antibody Induces Apoptosis of Breast Cancer Cells, Inhibits Growth, and Distinguishes Malignant from Normal Phenotype in Three Dimensional Cultures and In vivo. Cancer Research. 2006 Feb;66(3):1526-35.
  • Radisky DC, Bissell MJ. Matrix metalloproteinase-induced genomic instability. Curr Opinion Genet Dev.2006 Feb;16(1):45-50.
  • Liu H, Radisky DC, Nelson CM, Zhang H, Fata J and Bissell MJ. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci U S A. 2006 Mar;103(11):4134-9.
  • Semeiks JR, Rizki A, Bissell MJ and Mian IS. Ensemble attribute profile clustering: discovering and characterizing groups of genes with similar patterns of biological features. BMC Bioinformatics. 2006 Mar;7(1):147.
  • Knowles DW, Sudar D, Bator-Kelly C, Bissell MJ , and Lelievre SA. Automated local bright feature image analysis of nuclear protein distribution identifies changes in tissue phenotype. Proc Natl Acad Sci U S A. 2006 Mar;103(12):4445-50.
  • Kenny PA, Nelson CM and Bissell, MJ. The Ecology of Tumors. The Scientist 2006;20, 30-35.
  • Fournier MV, Martin KJ, Kenny PA, Xhaja K, Bosch I, Yaswen P and Bissell, MJ (2006). Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer. Cancer Research. 2006 Jul;66(14):7095-102.
  • Nelson CM and Bissell MJ. Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer. Annual Review of Cell and Developmental Biology – Review Article for Volume 22. 2006 Sep; [Epub ahead of print].
  • Weir ML, Oppizzi ML, Henry MD, Onishi A, Campbell KP, Bissell MJ and Muschler JL. Dystroglycan loss disrupts polarity and ß -casein induction in mammary epithelial cells by perturbing laminin anchoring. J Cell Sci.2006 Oct;119(Pt 19):4047-58.
  • Nelson, CM, van Duijn M, Inman JL, Fletcher DA and Bissell MJ. Tissue Geometry Determines Sites of Branching Morphogenesis in Organotypic Cultures. Science 2006 Oct;314(5797):298-300.
  • Tölg C, Hamilton SR, Nakrieko KA, Walton P, McCarthy JB, Bissell MJ , Turley EA . Rhamm-/- fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair. Journal of Cell Biology. 2006 Dec;175(6):1017-28.


  • Lelievre SA and Bissell MJ (2005). Three dimensional cell culture: the importance of microenvironment in regulation of function. In: Meyers RA, ed., Encyclopedia of Molecular Cell Biology and Molecular Medicine, Vol. 14.
  • Gudjonsson T, Adriance MC, Sternlicht MD, Petersen OW and Bissell MJ (2005). Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. J Mammary Gland Biol Neoplasia. 2005 Jul; 10(3):261-72.
  • Bissell MJ, Kenny PA, Radisky DC. Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes.Cold Spring Harb Symp Quant Biol. 2005;70:1-14.
  • Bascom JL, Fata JE, Hirai Y, Sternlicht MD, Bissell MJ. Epimorphin overexpression in the mouse mammary gland promotes alveolar hyperplasia and mammary adenocarcinoma. Cancer Res. 2005 Oct 1;65(19):8617-21.
  • Adriance MC, Inman JL, Petersen OW, Bissell MJ. Myoepithelial cells: good fences make good neighbors. Breast Cancer Res. 2005;7(5):190-7.
  • Krakowski AR, Laboureau J, Mauviel A, Bissell MJ, Luo K. From the Cover: Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-{beta} signaling by sequestration of the Smad proteins.Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12437-42.
  • Wu W, Xing EP, Myers C, Mian IS, Bissell MJ.
    Evaluation of normalization methods for cDNA microarray data by k-NN classification.BMC Bioinformatics. 2005 Jul 26;6(1):191
  • Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson DG, Nieto MA, Werb Z, Bissell MJ. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability.Nature. 2005 Jul 7;436(7047):123-7.
  • Nelson CM, Bissell MJ.Modeling dynamic reciprocity: Engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation.Semin Cancer Biol. 2005 Oct;15(5):342-52.
  • Liu H, Radisky DC, Bissell MJ.Cell Cycle.
    Proliferation and polarity in breast cancer: untying the gordian knot. Cell Cycle.2005 May;4(5):646-9.
  • Maniotis AJ, Valyi-Nagy K, Karavitis J, Moses J, Boddipali V, Wang Y, Nunez R, Setty S, Arbieva Z, Bissell MJ, Folberg R. Chromatin Organization Measured by AluI Restriction Enzyme Changes with Malignancy and Is Regulated by the Extracellular Matrix and the Cytoskeleton. Am J Pathol. 2005 Apr;166(4):1187-203.
  • Kaminker P, Plachot C, Kim SH, Chung P, Crippen D, Petersen OW, Bissell MJ, Campisi J, Lelievre SA. Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. J Cell Sci. 2005 Mar 15;118(Pt 6):1321-30. Epub 2005 Mar 1.
  • Bissell MJ, Labarge MA. Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment? Cancer Cell. 2005 Jan;7(1):17-23.




  • Fata JE, Werb, Z and Bissell MJ (2004). Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res. 2004; Review 6:1-11.
  • Rizki A and Bissell MJ (2004). Extracellular matrix: tissue specific regulator of cell proliferation. In: Stein GS and Pardee AB, eds., Cell Cycle & Growth Control: Biomolecular Regulation and Cancer, 9:297-332. NJ: John Wiley & Sons, Inc.
  • Turley EA and Bissell MJ (2004). Extracellular matrix remodeling in breast branching morphogenesis and breast cancer: the double-edged sword. In: Davies J, ed., Branching Morphogenesis, 7:121-37. Landes/Eurekah.
  • Alcaraz J, Nelson CM and Bissell MJ (2004). Biomechanical approaches for studying integration of tissue structure and function in mammary epithelia. J Mammary Gland Biol Neoplasia. 2004 Oct; 9(4):361-74.
  • Singh J, Itahana Y, Knight-Krajewski S, Kanagawa M, Campbell KP, Bissell MJ, Muschler J. Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells. Cancer Res. 2004 Sep 1;64(17):6152-9.
  • Rizki A, Bissell MJ.Homeostasis in the breast: it takes a village. Cancer Cell. 2004 Jul;6(1):1-2. Review
  • Blaustein M, Pelisch F, Coso OA, Bissell MJ, Kornblihtt AR, Srebrow A.Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via phosphatidylinositol 3-kinase. J Biol Chem. 2004 May 14;279(20):21029-37.
  • Liu H, Radisky DC, Wang F and Bissell MJ. Polarity and proliferation are controlled by distinct signaling pathways
    downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol. 2004 Feb 16;164(4):603-12. Epub 2004 Feb 09.
  • Radisky DC, Bissell MJ. 2004 Cancer. Respect thy neighbor! Science. Feb 6;303(5659):775-7.
  • Novaro V, Radisky DC, Ramos Castro NE, Weisz A, Bissell MJ. (2004) Malignant mammary cells acquire independence from extracellular context for regulation of estrogen receptor alpha. Clin Cancer Res Jan 1;10(1 Pt 2):402S-9S.
  • Come SE, Buzdar AU, Arteaga CL, Bissell MJ, Brown MA, Ellis MJ, Goss PE, Green JE, Ingle JN, Lee AV, Medina D, Nicholson RI, Santen RJ, Schiff R, Hart CS. Proceedings of the third international conference on recent advances and future directions in endocrine manipulation of breast cancer: conference summary statement. Clin Cancer Re. 2004 Jan 1;10(1 Pt 2):327S-30S.


  • Bhatacharyya C, Grate LR, Rizki A, Radisky D, Molina FJ, Jordan MI, Bissell MJ and Mian IS (2003). Simultaneous relevant feature identification and classification in high-dimensional spaces: Application to molecular profiling data. Signal Process. 83(4):729-43.
  • Radisky DC, Hirai Y and Bissell MJ (2003). Delivering the message: epimorphin and mammary epithelial morphogenesis. Trends Cell Biol. 2003 Aug; 13(8):426-34.
  • Itoh M and Bissell MJ (2003). The Organization of Tight Junctions in Epithelia: Implications for Mammary Gland Biology and Breast Tumorigenesis. J Mammary Gland Biol Neoplasia. 2003 Oct; 4:449-62.
  • Bissell MJ, Mian IS, Radisky D and Turley E. (2003) Tissue-specificity: Structural cues allow diverse phenotypes from a constant genotype. In: Origination of Organismal Form: Beyond the Gene in Developmental and Evolutionary Biology, Müller GB and Newman SA (Eds.). The Vienna Series in Theoretical Biology. MIT Press 7:103-117.Radisky, DC, Hirai, Y and Bissell MJ. (2003)
  • Petersen OW, Nielsen HL, Gudjonsson T, Villadsen R, Rank F, Niebuhr E, Bissell MJ and Rønnov-Jessen L. (2003) Epithelial to Mesenchymal transition in human breast cancer can provide a nonmalignant stroma. Am J Pathol 162:2:391-402.
  • Kenny, PA and Bissell MJ. (2003) Tumor reversion: Correction of malignant behavior by microenvironmental cues. Int J Cancer Review 107(5):588-695.
  • Bissell MJ, Rizki A, Mian IS (2003) Tissue architecture: the ultimate regulator of breast epithelial function. Curr Opin Cell Biol Dec;15(6):753-62.
  • Park C, Zhang H, Peng M, Bissell MJ. (2003) Cell-ECM mediated radiation response in breast cancer: beta1 integrin as a potential molecular target. Int J Radiat Oncol Biol Phy Oct 1;57(2 Suppl):S161.
  • Petersen OW, Gudjonsson T, Villadsen R, Bissell MJ, Ronnov-Jessen L. (2003) Epithelial progenitor cell lines as models of normal breast morphogenesis and neoplasia. Cell Prolif. Oct;36 Suppl 1:33-44. Review.
  • Wiseman BS, Sternlicht MD, Lund LR, Alexander CM, Mott J, Bissell MJ, Soloway P, Itohara S and Werb Z. (2003) Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. Journal of Cell Biology 162 (6):1123-1133.
  • Park, CC, Henshall-Powell, RL, Erickson, AC, Talhouk, R, Parvin, B, Bissell MJ and Barcellos-Hoff MH. Ionizing radiation induces heritable disruption of epithelial cell interactions. Proc Natl Acad Sci 100:19:10728-10733.
  • Gudjonsson T, Ronnov-Jessen L, Villadsen R, Bissell MJ, Petersen OW. (2003) To create the correct microenvironment: three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia. Methods Jul;30(3):247-55.
  • Novaro V, Roskelley C and Bissell MJ. (2003) Collagen-IV or laminin-1 together with lactogenic hormones regulate estrogen receptor-alpha expression and function in mouse mammary epithelial cells. J Cell Science 116(14) 2975-2986.
  • Schmeichel, KL and Bissell MJ. (2003) Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci. 116:2377-2388.
  • Anders M, Hansen R, Ding R-X, Waldman FW, Rauen K, Bissell MJ, and Korn WM. (2003) Disruption of 3D tissue integrity facilitates adenovirus infection by deregulating the coxsackievirus and adenovirus receptor. Proc Natl Acad Sci 100:4:1943-1948.
  • Bissell MJ and Bilder D. (2003) COMMENTARY: Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin 1. Breast Cancer Res 5:2:117-119.


  • Boudreau N and Bissell MJ (2002). Extracellular matrix: The networking solution. In: Alison MA, ed., The Molecular Basis of Cell and Tissue Organisation. The Cancer Handbook, pp. 209-24. London, New York and Tokyo: Nature Publishing Group. Vol. 1 of 2, Ch. 15.
  • Radisky D, Muschler J and Bissell MJ (2002). Order and disorder: the role of extracellular matrix in epithelial cancer. Cancer Invest. 2002; 20(1):139-53.
  • Bissell MJ, Le Beyec J and Anderson RL (2002). Prostate cancer in bone: importance of context for inhibition of matrix metalloproteinases. J Natl Cancer Inst. 2002 Jan 2; 94(1):4-5.
  • Roskelley CD and Bissell MJ (2002). The dominance of the microenvironment in breast and ovarian cancer. Semin Cancer Biol. 2002 Apr; 12(2):97-104.
  • Gudjonsson T, Rønnov-Jessen L, Villadsen R, Bissell MJ and Petersen OW. (2002) Normal and tumor-derived myoepithelial cells differ in their ability to signal to luminal breast epithelial cells for polarity and basement membrane deposition. J Cell Science 115(1):39-50.
  • Gudjonsson T, Villadsen R, Nielsen HL, Rønnov-Jensen L, Bissell MJ, and Petersen OW. (2002) Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes & Development 16(6):693-706.
  • Wang F, Hansen RK, Radisky D, Yoneda T, Barcellos-Hoff MH, Petersen OW, Turley EA and Bissell MJ. (2002) Phenotypic Reversion or Death of Cancer Cells by Altering Signaling Pathways in Three-Dimensional Contexts. J Nat'l Cancer Inst 94(19):1494-1503.
  • Weaver VM, Lelièvre SA, Lakins JN, Chrenek MA, Jones JCR, Giancotti F, Werb Z and Bissell MJ. (2002) b4 Integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2:205-216; News & Views, Nature 419:790-791 (2002). Minireview (Cell) 111:923-925 (2002).
  • Bissell MJ, Radisky D, Rizki A, Weaver, VM and Petersen, OW. (2002) The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation 70(9-10):537-46.
  • Muschler J, Levy D, Boudreau R, Henry M, Campbell K and Bissell MJ. (2002) A role for dystroglycan in epithelial polarization: Loss of function in breast tumor cells. Cancer Research 62:7102-7109.


  • Petersen OW, Nielsen HL, Gudjonsson T, Villadsen R, Rønnov-Jessen L and Bissell MJ (2001). The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion. Breast Cancer Res. 2001; 3(4):213-7.
  • Pujuguet P, Radisky D, Levy D, Lacza C and Bissell MJ (2001). Trichostatin A inhibits ?-casein expression in mammary epithelial cells. J Cell Biochem. 2001; 83(4):660-70.
  • Radisky D, Hagios C and Bissell MJ (2001). Tumors are unique organs defined by abnormal signaling and context. Semin Cancer Biol. 2001 Apr; 11(2):87-95.
  • Bissell MJ and Radisky D (2001). Putting tumours in context. Nat Rev Cancer. 2001 Oct; 1(1):46-54.
  • Zantek ND, Walker-Daniels J, Stewart J, Hansen RK, Robinson D, Miao H, Wang B, Kung HJ, Bissell MJ and Kinch MS (2001). MCF-10A-NeoST: A new cell system for studying cell-ECM and cell-cell interactions in breast cancer. Clin Cancer Res. 2001 Nov; 7:3640-8.
  • Hirai Y, Radisky D, Boudreau R, Simian M, Stevens M, Oka Y, Takebe K, Niwa S and Bissell MJ. (2001) Epimorphin mediates mammary luminal morphogenesis through control of C/EBPb. J Cell Biol 153(4):785-794.
  • Simian M, Hirai Y, Navre M, Werb Z, Lochter A and Bissell MJ. (2001) The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells. Development 28:3117-3131.
  • Muthuswamy SK, Li D, Lelièvre SA, Bissell MJ and Brugge JS. (2001) Erbb2, but not Erbb1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nature Cell Biol 3(9):785-792.


  • Lelièvre SA, Bissell MJ and Pujuguet P (2000). Cell nucleus in context. Crit Rev Eukaryot Gene Expr. 2000; 10(1):13-20.
  • Sternlicht MD, Bissell MJ and Werb Z (2000). The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter. Oncogene. 2000 Feb 21; 19(8):1102-13.
  • Hansen R and Bissell MJ (2000). Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones. Endocr Relat Cancer. 2000 Jun; 7(2):95-113.
  • Park CC, Bissell MJ and Barcellos-Hoff MH (2000). The influence of the microenvironment on the malignant phenotype. Mol Med Today. 2000 Aug; 6(8):324-9.
  • Chen M, Schmeichel K, Mian IS, Lelièvre SA, Petersen OW and Bissell MJ. (2000) AZU-1: A candidate breast tumor suppressor and biomarker for tumorigenic reversion. Mol Biol Cell 11(4):1357-1367.
  • Pujuguet P, Simian M, Liaw J, Timpl R, Werb Z and Bissell MJ. (2000) Nidogen-1 regulates laminin-1-dependent mammary-specific gene expression. J Cell Sci 113 (Pt 5):849-858 (cover feature).


  • Bissell MJ and Nelson JW, eds. (1999). Cell-to-cell contact and extracellular matrix integration of form and function: The central role of adhesion molecules. Curr Opin Cell Biol. 11:537-9.
  • Lochter A and Bissell MJ (1999). An odyssey from breast to bone: multi-step control of mammary metastases and osteolysis by matrix metalloproteinases. APMIS. 1999 Jan; 107(1):128-36.
  • Barash I, Faerman A, Richenstein M, Kari R, Damary GM, Shani M and Bissell MJ (1999). In vivo and in vitro expression of human serum albumin genomic sequences in mammary epithelial cells with b-lactoglobulin and whey acidic protein promoters. Mol Reprod Dev. 1999 Mar; 52:241-52.
  • Weaver VM and Bissell MJ (1999). Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia. 1999 Apr; 4(2):193-201.
  • Lochter A, Werb Z and Bissell MJ (1999). Transcriptional regulation of stromelysin-1 gene expression is altered during progression of mouse mammary epithelial cells from functionally normal to malignant. Matrix Biol. 1999 Oct; 18(5):455-67.
  • Spancake KM, Anderson CB, Weaver VM, Matsunami N, Bissell MJ and White RL (1999). E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture. Cancer Res. 1999 Dec 15; 59(24):6042-5.
  • Bissell MJ, Weaver VM, Lelièvre SA, Wang F, Petersen OW and Schmeichel KL. (1999) Tissue structure, nuclear organization and gene expression in normal and malignant breast. Cancer Res. 59:1757s-1764s.
  • Lochter A, Navre M, Werb Z and Bissell MJ. (1999) Alpha1 and alpha2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression. Mol Biol Cell 10:271-282.
  • Muschler J, Lochter A, Roskelley CR, Yurchenco P and Bissell MJ. (1999) Division of labor among the a6ß4 integrins, and an E3 laminin receptor to signal morphogenesis and ß-casein expression in mammary epithelial cells. Mol Biol Cell 10(9):2817-28.
  • Péchoux C, Gudjonsson T, Rønnov-Jessen L, Bissell MJ and Petersen OW. (1999) Human mammary luminal epithelial cells contain progenitors to myoepithelial cells. Develop Biol 206:88-99.
  • Sternlicht MD, Lochter A, Sympson CJ, Huey B, Rougier J-P, Gray J, Pinkel D, Bissell MJ, and Werb Z. (1999) The stromal proteinase MMP-3/stromelysin-1 promotes mammary carcinogenesis. Cell 98(2):137-146.
  • Bissell MJ. (1999) Tumor plasticity allows vasculogenic mimicry, a novel form of angiogenic switch: A rose by any other name? Am J Pathol 155(3):675-9.


  • Lelièvre SA and Bissell MJ (1998). Communication between the cell membrane and the nucleus: role of protein compartmentalization. J Cell Biochem Suppl. 1998; 30/31:250-63.
  • Petersen OW, Rønnov-Jessen L, Weaver VM and Bissell MJ (1998). Differentiation and cancer in the mammary gland: shedding light on an old dichotomy. Adv Cancer Res. 1998; 75:135-61.
  • Schmeichel KL, Weaver VM and Bissell MJ (1998). Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype. J Mammary Gland Biol Neoplasia. 1998 Apr; 3(2):201-13.
  • Bissell MJ (1998). Glandular structure and gene expression. Lessons from the mammary gland. 1998 Apr 15; In: Kukuruzinska MA & Tabak LA, eds., Salivary Gland Biogenesis and Function, 842:1-6. New York: Academic Science.
  • Srebrow A, Friedmann Y, Ravanpay A, Daniel CW and Bissell MJ (1998). Expression of Hoxa-1 and Hoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells. J Cell Biochem. 1998 Jun 15; 69(4):377-91.
  • Hagios C, Lochter A and Bissell MJ (1998). Tissue architecture: the ultimate regulator of epithelial function? Phil Trans R Soc London B Biol Sci. 1998 Jun 29; 353(1370):857-70.
  • Desprez P-Y, Lin CQ, Thomasset N, Sympson CJ, Bissell MJ and Campisi J (1998). A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1. Mol Cell Biol. 1998 Aug; 18(8):4577-88.
  • Thomasset N, Lochter A, Sympson CJ, Lund LR, Williams DR, Behrendtsen O, Werb Z and Bissell MJ (1998). Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development. Am J Pathol. 1998 Aug; 153(2):457-67.
  • Boudreau N and Bissell MJ (1998). Extracellular matrix signaling: integration of form and function in normal and malignant cells. Curr Opin Cell Biol. 1998 Oct; 10(5):640-6.
  • Lochter A, Sternlicht MD, Werb Z and Bissell MJ (1998). The significance of matrix metalloproteinases during early stages of tumor progression. Ann NY Acad Sci. 1998 Oct 23; 857:180-93.
  • Hirai Y, Lochter A, Galosy S, Koshida S, and Bissell MJ. (1998) Epimorphin functions as a key morphoregulator for mammary epithelial cells. J Cell Biol 140:159-169.
  • Lelièvre SA, Weaver VM, Nickerson JA, Larabell CA, Bhaumik A, Petersen OW and MJ Bissell MJ. (1998) Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus. Proc Natl Acad Sci USA 95:14711-14716.
  • Myers CA, Schmidhauser C, Mellentin-Michelotti J, Fragoso G, Roskelley CD, Casperson G, Mossi R, Pujuguet P, Hager G and Bissell MJ. (1998) Characterization of BCE-1: A transcriptional enhancer regulated by prolactin and extracellular matrix and modulated by the state of histone acetylation. Mol Cell Biol 18(4):2184-2195.
  • Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R and Bissell MJ. (1998) Reciprocal interactions between ß1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology. Proc Natl Acad Sci USA 95:14821-14826.


  • Bissell MJ (1997). The central role of basement membrane in functional differentiation, apoptosis and cancer. In: Tilly JL, Strauss III JF & Tenniswood M, eds., Cell Death in Reproductive Physiology, pp. 125-40. Serono Symposia USA.
  • Lelièvre SA, Weaver VM, Larabell CA and Bissell MJ (1997). Extracellular matrix and nuclear matrix interactions may regulate apoptosis and tissue-specific gene expression: A concept whose time has come. Adv in Mol Cell Biol. 24:1-55.
  • Lochter A and Bissell MJ (1997). Mammary gland biology and the wisdom of extracellular matrix. In: Wilde CJ et al., eds., Biological Signalling and the Mammary Gland, pp. 77-92.
  • Pujuguet P and Bissell MJ (1997). Dynamic reciprocity: The extracellular matrix and the molecular dialogue. Helix. 6:16-25.
  • Lochter A, Galosy S, Muschler J, Freedman N, Werb Z and Bissell MJ. (1997) Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells. J Cell Biol 139:1861-1872.
  • Lochter A, Srebrow A, Sympson CJ, Terracio N, Werb Z and Bissell MJ. (1997) Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties. J Biol Chem 272:5007-5015.
  • Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C and Bissell MJ. (1997) Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo using integrin blocking antibodies. J Cell Biol 137:231-246 (cover feature).


  • Boudreau N and Bissell MJ (1996). Regulation of gene expression by the extracellular matrix. In: Comper WD, ed., Extracellular Matrix, Volume 2, Molecular Components and Interactions, pp. 246-61. Overseas Publishers Association.
  • Chen H, Weaver VM, Petersen OW and Bissell MJ (1996). Extracellular matrix as a central regulator of function, growth and programmed death in breast cells of both mice and men: Implications for therapy. J Pezcoller Foundation. 7:2-10.
  • Lelièvre S, Weaver VM and Bissell MJ (1996). Extracellular matrix signaling from the cellular membrane skeleton to the nuclear skeleton: a model of gene regulation. Recent Prog Horm Res. 1996; 51:417-32.
  • Weaver VM, Fischer AH, Petersen OW and Bissell MJ (1996). The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay. Biochem. Cell Biol. 1996; 74(6): 833-51.
  • Lund LR, Romer J, Thomasset N, Solberg H, Pyke C, Bissell MJ, Dano K and Werb Z (1996). Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. Development. 1996 Jan; 122:181-93.
  • Boudreau N, Werb Z and Bissell MJ (1996). Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle. Proc Natl Acad Sci USA. 1996 Apr 16; 93(8):3509-13.
  • Werb Z, Sympson CJ, Alexander CM, Thomasset N, Lund LR, MacAuley A, Ashkenas J and Bissell MJ (1996). Extracellular matrix remodeling and the regulation of epithelial-stromal interactions during differentiation and involution. Kidney Intl Suppl. 1996 May; 49:S68-S74.
  • Alexander CM, Howard EW, Bissell MJ and Werb Z (1996). Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene. J Cell Biol. 1996 Dec; 135(6):1669-77.
  • Ashkenas J, Muschler J and Bissell MJ (1996). The extracellular matrix in epithelial biology: shared molecules and common themes in distant phyla. Dev Biol. 1996 Dec 15; 180(2):433-44.
  • Rønnov-Jessen L, Petersen OW and Bissell MJ. (1996) Cellular changes involved in conversion of normal to malignant breast: The importance of the stromal reaction. Physiol Revs 76:69-125.


  • Boudreau N, Reddy ST, Stoker AW, Fairman C and Bissell MJ (1995). The embryonic environment and the extracellular matrix suppress oncogenic transformation by Rous sarcoma virus in the chick embryo. Mol Cell Differ. 3:261-74.
  • Martins-Green M and Bissell MJ (1995). Cell-ECM interactions in development. Semin Dev Biol. 6:149-59.
  • Petersen OW, Rønnov-Jessen L and Bissell MJ (1995). The microenvironment of the breast: Three-dimensional models to study the roles of the stroma and the extracellular matrix in function and dysfunction. Breast J. 1:22-35.
  • Schmidhauser C, Myers CA, Mossi R, Casperson C and Bissell MJ (1995). Extracellular matrix dependent gene regulation in mammary epithelial cells. In: Wilde CJ et al., eds., Intercellular Signalling and the Mammary Gland, pp.107-19. New York: Plenum Press.
  • Sympson CJ, Talhouk R, Bissell MJ and Werb Z (1995). The role of metalloproteinases and their inhibitors in regulating mammary epithelial morphology and function in vivo. Perspect Drug Discov. 2(3):401-11.
  • Boudreau N, Myers C and Bissell MJ (1995). From laminin to lamin: regulation of tissue-specific gene expression by the ECM. Trends Cell Biol. 1995 Jan; 5(1):1-4.
  • Jones PL, Boudreau N, Meyers CA, Erickson HP and Bissell MJ (1995). Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments J Cell Sci. 1995 Feb; 108:519-27.
  • Howlett AR, Bailey N, Damsky C, Petersen OW and Bissell MJ (1995). Cellular growth and survival are mediated by b-1 integrins in normal human breast epithelium but not in breast carcinoma. J Cell Sci. 1995 May; 108:1945-57.
  • Bissell MJ and Werb Z, eds. (1995). Introduction: basic science aspects of breast cancer. Semin Cancer Biol. 1995 Jun; 6(3):117-8.
  • Desprez PY, Hara E, Bissell MJ and Campisi J (1995). Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1. Mol Cell Biol. 1995 Jun; 15(6):3398-404.
  • Lochter A and Bissell MJ (1995). Involvement of extracellular matrix constituents in breast cancer. Semin Cancer Biol. 1995 Jun; 6(3):165-73.
  • Sympson CJ, Bissell MJ and Werb Z (1995). Mammary gland tumor formation in transgenic mice over-expressing stromelysin-1. Semin Cancer Biol. 1995 Jun; 6(3):159-63.
  • Weaver VM, Howlett AR, Langston-Weber B, Petersen OW and Bissell MJ (1995). The development of a functionally relevant cell culture model of progressive human breast cancer. Semin Cancer Biol. 1995 Jun; 6(3):175-84.
  • Roskelley CD and Bissell MJ (1995). Dynamic reciprocity revisited: a continuous, bidirectional flow of information between cells and the extracellular matrix regulates mammary epithelial cell function. Biochem Cell Biol. 1995 Jul-Aug; 73(7-8):391-7.
  • Roskelley CD, Srebrow A and Bissell MJ (1995). A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression. Curr Opin Cell Biol. 1995 Oct; 7(5):736-47.
  • Streuli CH, Schmidhauser C, Bailey N, Yurchenco P, Skubitz A and Bissell MJ. (1995) Laminin mediates tissue-specific gene expression in mammary epithelia. J Cell Biol 129:591-603.
  • Rønnov-Jessen L, Petersen OW, Kotelianski V and Bissell MJ. (1995) The origin of the myofibroblasts in breast cancer: Recapitulation of tumor environment in culture unravels diversity and implicates coverted fibroblasts and recruited smooth muscle cells. J Clinical Investigation 95:859-873.
  • Lin CQ, Dempsey P, Coffey C and Bissell MJ. (1995) Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-a in mouse mammary epithelial cells: Studies in culture and in transgenic mice. J. Cell Biol 129(4):1115-1126.
  • Boudreau N, Sympson CJ, Werb Z and Bissell MJ. (1995) Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267:891-893.



1970- 2004

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  • Ashkenas J, Damsky CH, Bissell MJ and Werb Z (1994). Integrins, signaling and the remodeling of the extracellular matrix. In: Cheresh D & Mecham R, eds., The Integrins, pp. 79-109. Academic Press.
  • Howlett, A. R., Petersen, O. W., Steeg, P. S. and Bissell, M. J. (1994). A novel function for the nm23-H1 gene: overexpression in human breast carcinoma cells leads to the formation of basement membrane and growth arrest. J Natl Cancer Inst 86, 1838-44.
  • Roskelley, C. D., Desprez, P. Y. and Bissell, M. J. (1994). Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction. Proc Natl Acad Sci U S A 91, 12378-82.
  • Martins-Green, M., Boudreau, N. and Bissell, M. J. (1994). Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus. Cancer Res 54, 4334-41.
  • Schmidhauser, C., Casperson, G. F. and Bissell, M. J. (1994). Transcriptional activation by viral enhancers: critical dependence on extracellular matrix-cell interactions in mammary epithelial cells. Mol Carcinog 10, 66-71.
  • Sympson, C. J., Talhouk, R. S., Alexander, C. M., Chin, J. R., Clift, S. M., Bissell, M. J. and Werb, Z. (1994). Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J Cell Biol 125, 681-93.
  • Sieweke, M. H. and Bissell, M. J. (1994). The tumor-promoting effect of wounding: a possible role for TGF-beta-induced stromal alterations. Crit Rev Oncog 5, 297-311.
  • Blaschke, R. J., Howlett, A. R., Desprez, P. Y., Petersen, O. W. and Bissell, M. J. (1994). Cell differentiation by extracellular matrix components. Methods Enzymol 245, 535-56.



  • Bissell MJ and Wicha MS (1993). Extracellular matrix is required for milk protein gene expression and secretion in mammary epithelial cells. In: Houdebine LM, ed., Biology of Lactation. France: INRA.
  • Desprez P-Y, Roskelley CD, Campisi J and Bissell MJ (1993). Isolation of functional cell lines from a mouse mammary epithelial cell strain: The importance of basement membrane and cell-cell interaction. Mol Cell Differ. 1:99-110.
  • Roskelley CD, Petersen OW and Bissell MJ (1993). The significance of the extracellular matrix in mammary epithelial carcinogenesis. In: Heppner G, ed., Biology of the Cancer Cell. Greenwich, CT: JAI Press, Inc.
  • Talhouk RS, Streuli CH, Barcellos-Hoff MH and Bissell MJ (1993). The extracellular matrix. In: Bittar EE, ed., Fundamentals of Medical Cell Biology, pp. 137-78. Greenwich, CT: JAI Press, Inc.
  • Talhouk RS, Werb Z and Bissell MJ (1993). Functional interplay between ECM and ECM-degrading proteinases in the mammary gland: A coordinate system for regulating mammary epithelium function. In: Fleming T, ed., Epithelial Organization and Development. London, England: Chapman and Hall.
  • Bissell MJ (Ed.) (1993). Form and function in the epithelia. In: Seminars in Cell Biol. London, England: Saunders Scientific Publications/Academic Press, June.
  • Lin, C. Q. and Bissell, M. J. (1993). Multi-faceted regulation of cell differentiation by extracellular matrix. Faseb J 7, 737-43.
  • Howlett, A. R. and Bissell, M. J. (1993). The influence of tissue microenvironment (stroma and extracellular matrix) on the development and function of mammary epithelium. Epithelial Cell Biol 2, 79-89.
  • Streuli, C. H., Schmidhauser, C., Kobrin, M., Bissell, M. J. and Derynck, R. (1993). Extracellular matrix regulates expression of the TGF-beta 1 gene. J Cell Biol 120, 253-60.
  • Jones, P. L., Schmidhauser, C. and Bissell, M. J. (1993). Regulation of gene expression and cell function by extracellular matrix. Crit Rev Eukaryot Gene Expr 3, 137-54.



  • Werb Z, Talhouk R, Sympson C, Alexander C and Bissell MJ (1992). The role of metalloproteinases and their inhibitors in tissue remodeling in the mammary gland. In: Tissue Injury and Proteases, pp. 177-82.
  • Petersen, O. W., Ronnov-Jessen, L., Howlett, A. R. and Bissell, M. J. (1992). Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci U S A 89, 9064-8.
  • Talhouk, R. S., Bissell, M. J. and Werb, Z. (1992). Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution. J Cell Biol 118, 1271-82.
  • Schmidhauser, C., Casperson, G. F., Myers, C. A., Sanzo, K. T., Bolten, S. and Bissell, M. J. (1992). A novel transcriptional enhancer is involved in the prolactin- and extracellular matrix-dependent regulation of beta-casein gene expression. Mol Biol Cell 3, 699-709.
  • Dale, T. C., Krnacik, M. J., Schmidhauser, C., Yang, C. L., Bissell, M. J. and Rosen, J. M. (1992). High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region. Mol Cell Biol 12, 905-14.
  • Martins-Green, M., Aotaki-Keen, A., Hjelmeland, L. M. and Bissell, M. J. (1992). The 9E3 protein: immunolocalization in vivo and evidence for multiple forms in culture. J Cell Sci 101 ( Pt 3), 701-7.
  • Parry, G., Li, J., Stubbs, J., Bissell, M. J., Schmidhauser, C., Spicer, A. P. and Gendler, S. J. (1992). Studies of Muc-1 mucin expression and polarity in the mouse mammary gland demonstrate developmental regulation of Muc-1 glycosylation and establish the hormonal basis for mRNA expression. J Cell Sci 101 ( Pt 1), 191-9.



  • Schmidhauser C, Casperson GF, Myers CA and Bissell MJ (1991). Extracellular matrix and hormones regulate bovine b-casein gene 5’ sequences in stably transfected mouse mammary cells. In: Lippman M & Mihich H, eds., The Therapeutic Implications of the Molecular Biology of Breast Cancer, pp. 121-33. Rome, Italy: Centro Italiano Congressi, Proceedings of the Second Pezcoller Foundation Symposium. (Proc Natl Acad Sci USA. 87(23):9118-22)
  • Streuli, C. H., Bailey, N. and Bissell, M. J. (1991). Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity. J Cell Biol 115, 1383-95.
  • Reddy, S. T., Stoker, A. W. and Bissell, M. J. (1991). Expression of Rous sarcoma virus-derived retroviral vectors in the avian blastoderm: potential as stable genetic markers. Proc Natl Acad Sci U S A 88, 10505-9.
  • Martins-Green, M., Tilley, C., Schwarz, R., Hatier, C. and Bissell, M. J. (1991). Wound-factor-induced and cell cycle phase-dependent expression of 9E3/CEF4, the avian gro gene. Cell Regul 2, 739-52.
  • Aggeler, J., Ward, J., Blackie, L. M., Barcellos-Hoff, M. H., Streuli, C. H. and Bissell, M. J. (1991). Cytodifferentiation of mouse mammary epithelial cells cultured on a reconstituted basement membrane reveals striking similarities to development in vivo. J Cell Sci 99 ( Pt 2), 407-17.
  • Talhouk, R. S., Chin, J. R., Unemori, E. N., Werb, Z. and Bissell, M. J. (1991). Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture. Development 112, 439-49.
  • Streuli, C. H. and Bissell, M. J. (1991). Mammary epithelial cells, extracellular matrix, and gene expression. Cancer Treat Res 53, 365-81.



  • Howlett AR and Bissell MJ (1990). Regulation of mammary epithelial cell function: A role for stromal and basement membrane matrices. In: Keenan TW, ed., Stuart Patton Commemorative Issue of Protoplasma, pp. 85-95. Secaucus, NJ: Springer-Verlag New York, Inc.
  • Schmidhauser, C., Bissell, M. J., Myers, C. A. and Casperson, G. F. (1990). Extracellular matrix and hormones transcriptionally regulate bovine beta-casein 5' sequences in stably transfected mouse mammary cells. Proc Natl Acad Sci U S A 87, 9118-22.
  • Stoker, A. W., Streuli, C. H., Martins-Green, M. and Bissell, M. J. (1990a). Designer microenvironments for the analysis of cell and tissue function. Curr Opin Cell Biol 2, 864-74.
  • Stoker, A. W., Hatier, C. and Bissell, M. J. (1990b). The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia. J Cell Biol 111, 217-28.
  • Sieweke, M. H., Thompson, N. L., Sporn, M. B. and Bissell, M. J. (1990). Mediation of wound-related Rous sarcoma virus tumorigenesis by TGF-beta. Science 248, 1656-60.
  • Streuli, C. H. and Bissell, M. J. (1990). Expression of extracellular matrix components is regulated by substratum. J Cell Biol 110, 1405-15.
  • Auersperg, N., MacLaren, I. A. and Bissell, M. J. (1990). V-K-ras transformation induces reversion to an earlier developmental form in adult rat adrenal cells. Differentiation 43, 29-36.
  • Martins-Green, M. and Bissell, M. J. (1990). Localization of 9E3/CEF-4 in avian tissues: expression is absent in Rous sarcoma virus-induced tumors but is stimulated by injury. J Cell Biol 110, 581-95.
  • Bissell, M. J. (1990). Mammary gland as a model for studies of gene expression in normal and malignant cells. Prog Clin Biol Res 354A, 313-6.



  • Barcellos-Hoff MH and Bissell MJ (1989). Mammary epithelial cells as a model for studies of regulation of gene expression. In: Matlin K & Valentich JD, eds., Functional Epithelial Cells in Culture, pp. 399-433. New York, NY: Alan R. Liss, Inc.
  • Barcellos-Hoff MH and Bissell MJ (1989). A role for the extracellular matrix in autocrine and paracrine regulation of gene expression. Krey L, Gulyas BJ & McKraken M, eds., Paracrine and Autocrine Factors in Reproductive Endocrinology, pp. 137-55. New York, NY: Plenum Publishing Corporation.
  • Sieweke, M. H., Stoker, A. W. and Bissell, M. J. (1989). Evaluation of the cocarcinogenic effect of wounding in Rous sarcoma virus tumorigenesis. Cancer Res 49, 6419-24.
  • Chen, L. H. and Bissell, M. J. (1989). A novel regulatory mechanism for whey acidic protein gene expression. Cell Regul 1, 45-54.
  • Bissell, M. J. and Ram, T. G. (1989). Regulation of functional cytodifferentiation and histogenesis in mammary epithelial cells: role of the extracellular matrix. Environ Health Perspect 80, 61-70.
  • Barcellos-Hoff, M. H., Aggeler, J., Ram, T. G. and Bissell, M. J. (1989). Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane. Development 105, 223-35.



  • Bissell MJ and Aggeler J (1988). Regulation of tissue specific gene expression in the mammary gland: The role of extracellular matrix. In: Rich MA, Hager JC & Lopez DM, eds., Breast Cancer: Scientific & Clinical Progress, pp. 127-41. Boston, MA: Kluwer Academic Publishers.
  • Emerman JT and Bissell MJ (1988). Cultures of mammary epithelial cells: Extracellular matrix and functional differentiation. In: Maramorosch K & Sato GH, eds., Advances in Cell Culture, pp. 137-55. San Diego, CA: Academic Press, Inc.
  • Bissell MJ, Ram TG and Chen L (1988). Regulation of gene expression by extracellular matrix in higher eukaryotes. In: Gene Expression and Regulation: The Legacy of Luigi Gorini, pp. 279-87.
  • Parry, G., Farson, D., Cullen, B. and Bissell, M. J. (1988). p-nitrophenyl-beta-D-xyloside modulates proteoglycan synthesis and secretory differentiation in mouse mammary epithelial cell cultures. In Vitro Cell Dev Biol 24, 1217-22.
  • Aggeler, J., Park, C. S. and Bissell, M. J. (1988). Regulation of milk protein and basement membrane gene expression: the influence of the extracellular matrix. J Dairy Sci 71, 2830-42.
  • Howlett, A. R., Carter, V. C., Martin, G. S. and Bissell, M. J. (1988). pp60v-src tyrosine kinase is expressed and active in sarcoma-free avian embryos microinjected with Rous sarcoma virus. Proc Natl Acad Sci U S A 85, 7587-91.
  • Stoker, A. W. and Bissell, M. J. (1988). Development of avian sarcoma and leukosis virus-based vector-packaging cell lines. J Virol 62, 1008-15.



  • Bissell MJ and Hall HG (1987). Form and function in the mammary gland: The role of extracellular matrix. In: Nevell MC & Neville CWD, eds., The Mammary Gland: Development, Regulation and Function, pp. 97-146. New York: Plenum Publishing Corp.
  • Bissell MJ, Li M-L, Chen L-H and Lee EY-H (1987). Regulation of milk proteins in the mouse mammary epithelial Cells by extracellular matrix and hormones. In: Enami J & Ham R, eds., Growth and Differentiation of Mammary Epithelial Cells in Culture, pp. 155-86. Tokyo, Japan: Japan Scientific Societies Press.
  • Smith HS and Bissell MJ (1987). Cancer at the cellular level. Cancer Res. 47:3337-8.
  • Chen, L. H. and Bissell, M. J. (1987). Transferrin mRNA level in the mouse mammary gland is regulated by pregnancy and extracellular matrix. J Biol Chem 262, 17247-50.
  • Medina, D., Li, M. L., Oborn, C. J. and Bissell, M. J. (1987). Casein gene expression in mouse mammary epithelial cell lines: dependence upon extracellular matrix and cell type. Exp Cell Res 172, 192-203.
  • Stoker, A. W. and Bissell, M. J. (1987). Quantitative immunocytochemical assay for infectious avian retroviruses. J Gen Virol 68 ( Pt 9), 2481-5.
  • Howlett, A. R., Cullen, B., Hertle, M. and Bissell, M. J. (1987). Tissue tropism and temporal expression of Rous sarcoma virus in embryonic avian limb in ovo. Oncogene Res 1, 255-63.
  • Chan, L. M., Hatier, C., Parry, G., Werb, Z. and Bissell, M. J. (1987). Collagen-fibronectin interactions in normal and Rous sarcoma virus-transformed avian tendon cells: possible mechanisms for increased extracellular matrix turnover after transformation. In Vitro Cell Dev Biol 23, 308-14.
  • Lee, E. Y., Barcellos-Hoff, M. H., Chen, L. H., Parry, G. and Bissell, M. J. (1987). Transferrin is a major mouse milk protein and is synthesized by mammary epithelial cells. In Vitro Cell Dev Biol 23, 221-6.
  • Bissell, M. J. and Aggeler, J. (1987). Dynamic reciprocity: how do extracellular matrix and hormones direct gene expression? Prog Clin Biol Res 249, 251-62.
  • Li, M. L., Aggeler, J., Farson, D. A., Hatier, C., Hassell, J. and Bissell, M. J. (1987). Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells. Proc Natl Acad Sci U S A 84, 136-40.
  • Bissell, M. J. and Barcellos-Hoff, M. H. (1987). The influence of extracellular matrix on gene expression: is structure the message? J Cell Sci Suppl 8, 327-43.



  • Green AR, Searle S, Gillespie DAF, Bissell MJ and Wyke JA (1986). Expression of integrated Rous sarcoma viruses: DNA rearrangements 5' to the provirus are common in transformed rat cells but not seen in infected but untransformed cells. EMBO J. 5(4):707-11.
  • Carter, C., Howlett, A. R., Martin, G. S. and Bissell, M. J. (1986). The tyrosine phosphorylation substrate p36 is developmentally regulated in embryonic avian limb and is induced in cell culture. J Cell Biol 103, 2017-24.
  • Levantis, P., Gillespie, D. A., Hart, K., Bissell, M. J. and Wyke, J. A. (1986). Control of expression of an integrated Rous sarcoma provirus in rat cells: role of 5' genomic duplications reveals unexpected patterns of gene transcription and its regulation. J Virol 57, 907-16.
  • Hall, H. G. and Bissell, M. J. (1986). Characterization of the intermediate filament proteins of murine mammary gland epithelial cells. Response to collagen substratum. Exp Cell Res 162, 379-89.



  • Wyke JA, Bissell MJ, Gillespie DAF and Levantis P (1985). The molecular basis for phenotypic modulation in cells containing an integrated viral src oncogene. In: Dumont JE, Hamprecht B & Nunez J, eds., Hormones and Cell Regulation. Amsterdam, Holland: Elsevier Science Publishers B.V. (Biomedical Division) Vol. 9.
  • Bissell MJ, Lee EY-H, Li M-L, Chen L-H and Hall HG (1985). Role of extracellular matrix and hormones in modulation in tissue-specific functions in culture: Mammary gland as a model for endocrine sensitive tissues. In: Rogers CH, Coffey DC, Cunha GR, Grayhack JT, Hunman F and Horton R, eds. Benign Prostatic Hyperplasia, Vol. II, pp. 39-50. NIH Publication No. 87-2881.
  • Dolberg, D. S., Hollingsworth, R., Hertle, M. and Bissell, M. J. (1985). Wounding and its role in RSV-mediated tumor formation. Science 230, 676-8.
  • Kellie, S., Holme, T. C. and Bissell, M. J. (1985). Interaction of tumour promoters with epithelial cells in culture. An immunofluorescence study. Exp Cell Res 160, 259-74.
  • Lee, E. Y., Lee, W. H., Kaetzel, C. S., Parry, G. and Bissell, M. J. (1985). Interaction of mouse mammary epithelial cells with collagen substrata: regulation of casein gene expression and secretion. Proc Natl Acad Sci U S A 82, 1419-23.
  • Parry, G., Lee, E. Y., Farson, D., Koval, M. and Bissell, M. J. (1985). Collagenous substrata regulate the nature and distribution of glycosaminoglycans produced by differentiated cultures of mouse mammary epithelial cells. Exp Cell Res 156, 487-99.



  • Dolberg, D. S. and Bissell, M. J. (1984). Inability of Rous sarcoma virus to cause sarcomas in the avian embryo. Nature 309, 552-6.
  • Lee, E. Y., Parry, G. and Bissell, M. J. (1984). Modulation of secreted proteins of mouse mammary epithelial cells by the collagenous substrata. J Cell Biol 98, 146-55.
  • Packard, B. S., Saxton, M. J., Bissell, M. J. and Klein, M. P. (1984). Plasma membrane reorganization induced by tumor promoters in an epithelial cell line. Proc Natl Acad Sci U S A 81, 449-52.



  • Karczmar GS, Koretsky AP, Bissell MJ, Klein MP and Weiner MW (1983). A device for maintaining viable cells at high densities for NMR studies. J Magn Reson. 53:123-8.
  • Laszlo, A. and Bissell, M. J. (1983). TPA induces simultaneous alterations in the synthesis and organization of vimentin. Exp Cell Res 148, 221-34.



  • Parry G, Lee E and Bissell MJ (1982). Modulation of the differentiated phenotype of cultured mouse mammary epithelial cells by collagen substrata. In: The Extracellular Matrix, pp. 303-8.
  • Hall HG, Farson DA, Chin S and Bissell MJ (1982). Extracellular matrix and morphogenesis: collagen overlay induces lumen formation by epithelial cell lines. In: The Extracellular Matrix, pp. 233-8.
  • Bissell, M. J., Hall, H. G. and Parry, G. (1982). How does the extracellular matrix direct gene expression? J Theor Biol 99, 31-68.
  • Hall, H. G., Farson, D. A. and Bissell, M. J. (1982). Lumen formation by epithelial cell lines in response to collagen overlay: a morphogenetic model in culture. Proc Natl Acad Sci U S A 79, 4672-6.



  • Bissell, M. J., Nemethy, E. K., Riddle, L. and Calvin, M. (1981). Testing for tumor promoters in Euphorbia lathyris: analysis of possible health hazards. Bull Environ Contam Toxicol 27, 894-902.
  • Bartley, J. C., Emerman, J. T. and Bissell, M. J. (1981). Metabolic cooperativity between epithelial cells and adipocytes of mice. Am J Physiol 241, C204-8.
  • Laszlo, A., Radke, K., Chin, S. and Bissell, M. J. (1981). Tumor promoters alter gene expression and protein phosphorylation in avian cells in culture. Proc Natl Acad Sci U S A 78, 6241-5.
  • Schwarz, R. I., Mandell, R. B. and Bissell, M. J. (1981). Ascorbate induction of collagen synthesis as a means for elucidating a mechanism of quantitative control of tissue-specific function. Mol Cell Biol 1, 843-53.
  • Emerman, J. T., Bartley, J. C. and Bissell, M. J. (1981). Glucose metabolite patterns as markers of functional differentiation in freshly isolated and cultured mouse mammary epithelial cells. Exp Cell Res 134, 241-50.
  • Bissell, M. J. (1981). The differentiated state of normal and malignant cells or how to define a "normal" cell in culture. Int Rev Cytol 70, 27-100.



  • Parry, G., Bartholomew, J. C. and Bissell, M. J. (1980). Role of src gene in growth regulation of Rous sarcoma virus-infected chicken embryo fibroblasts. Nature 288, 720-2.
  • Vessal, M., Choun, M. O., Bissell, M. J. and Bissell, D. M. (1980). Fructose utilization and altered cytochrome P-450 in cultured hepatocytes from adult rats. Biochim Biophys Acta 633, 201-10.
  • Emerman, J. T., Bartley, J. C. and Bissell, M. J. (1980). Interrelationship of glycogen metabolism and lactose synthesis in mammary epithelial cells of mice. Biochem J 192, 695-702.
  • Bissell, M. J., Hatie, C., Farson, D. A., Schwarz, R. I. and Soo, W. J. (1980). Ascorbic acid inhibits replication and infectivity of avian RNA tumor virus. Proc Natl Acad Sci U S A 77, 2711-5.



  • Bissell MJ, Bartholomew JC, Folkman J, Smith H and Stampfer M (1979). Culture systems for studying malignancy. Meeting Report, Cancer Res. 39:4293-5 (with 19 other contributors).
  • Parry, G., Soo, W. J. and Bissell, M. J. (1979). The uncoupled regulation of fibronectin and collagen synthesis in Rous sarcoma virus transformed avian tendon cells. J Biol Chem 254, 11763-6.
  • Schwarz, R. I., Farson, D. A. and Bissell, M. J. (1979). Requirements for maintaining the embryonic state of avian tendon cells in culture. In Vitro 15, 941-8.
  • Emerman, J. T. and Bissell, M. J. (1979). A simple technique for detection and quantitation of lactose synthesis and secretion. Anal Biochem 94, 340-5.
  • Bissell, M. J., Hatie, C. and Calvin, M. (1979). Is the product of the src gene a promoter? Proc Natl Acad Sci U S A 76, 348-52.



  • Bissell MJ (1978). Equality for women scientists. Grants Magazine. 1(4):331-4.
  • Schwarz, R. I., Farson, D. A., Soo, W. J. and Bissell, M. J. (1978). Primary avian tendon cells in culture. An improved system for understanding malignant transformation. J Cell Biol 79, 672-9.
  • Levine, G. A., Bissell, M. J. and Bissell, D. M. (1978). Conversion of glucose to sorbitol and fructose by liver-derived cells in culture. J Biol Chem 253, 5985-9.
  • Bissell, D. M., Levine, G. A. and Bissell, M. J. (1978). Glucose metabolism by adult hepatocytes in primary culture and by cell lines from rat liver. Am J Physiol 234, C122-30.
  • Szabo, C. and Bissell, M. J. (1978). Antiviral action of a rifamycin derivative: formation Rous sarcoma virus particles deficient in 60 to 70S RNA. J Virol 25, 944-7.
  • Hughes, A. M., Tenforde, T. S., Calvin, M., Bissell, M. J., Tischler, A. N. and Bennett, E. L. (1978). Inhibition of adenocarcinoma TA3 ascites tumor growth by rifamycin derivatives. Oncology 35, 76-82.



  • Brooks, G. A., Bissell, M. J. and Bassham, J. A. (1977). Ion-retardation desalting of blood and other animal tissues for separation of soluble metabolites by two-dimensional chromatography. Anal Biochem 83, 580-8.
  • Chin, S., Bissell, M. J. and Bassham, J. A. (1977). The consequences of bisulfite exposure in primary chick embryo fibroblast in culture. Bull Environ Contam Toxicol 18, 749-57.
  • Schwarz, R. I. and Bissell, M. J. (1977). Dependence of the differentiated state on the cellular environment: modulation of collagen synthesis in tendon cells. Proc Natl Acad Sci U S A 74, 4453-7.
  • Teng, M. H., Bartholomew, J. C. and Bissell, M. J. (1977). Synergism between anti-microtubule agents and growth stimulants in enhancement of cell cycle traverse. Nature 268, 739-41.
  • Warshawsky, D., Kerns, E., Bissell, M. J. and Calvin, M. (1977). Characterization of a photoproduct of 7,12-dimethylbenz[alpha]anthracene and its effects on chick-embryo cells in culture. Biochem J 164, 481-6.
  • Neff, N. T., Ross, P. A., Bartholomew, J. C. and Bissell, M. J. (1977). Leucine in cultured cells: its metabolism and use as a marker for protein turnover. Exp Cell Res 106, 175-83.
  • Bissell, M. J., Farson, D. and Tung, A. S. (1977). Cell shape and hexose transport in normal and virus-transformed cells in culture. J Supramol Struct 6, 1-12.



  • Bissell, M. J. (1976). Transport as a rate limiting step in glucose metabolism in virus-transformed cells: studies with cytochalasin B. J Cell Physiol 89, 701-9.
  • Teng, M. H., Bartholomew, J. C. and Bissell, M. J. (1976). Insulin effect on the cell cycle: analysis of the kinetics of growth parameters in confluent chick cells. Proc Natl Acad Sci U S A 73, 3173-7.
  • DeFrancesco, L., Scheffler, I. E. and Bissell, M. J. (1976). A respiration-deficient Chinese hamster cell line with a defect in NADH-coenzyme Q reductase. J Biol Chem 251, 4588-95.
  • Szabo, C., Bissell, M. J. and Calvin, M. (1976). Inhibition of infectious Rous sarcoma virus production by rifamycin derivative. J Virol 18, 445-53.
  • Bissell, M. J., Rambeck, W. A., White, R. C. and Bassham, J. A. (1976). Glycerol phosphate shuttle in virus-transformed cells in culture. Science 191, 856-8.
  • Hawkes, S. P., Meehan, T. D. and Bissell, M. J. (1976). The use of fluorescamine as a probe for labeling the outer surface of the plasma membrane. Biochem Biophys Res Commun 68, 1226-33.



  • Dolberg, D. S., Bassham, J. A. and Bissell, M. J. (1975). Selective inhibition of the facilitated mode of sugar uptake by cytochalasin B in cultured chick fibroblasts. Exp Cell Res 96, 129-37.
  • Rambeck, W. A., Bissell, M. J. and Bassham, J. A. (1975). Metabolism in normal and virus-transformed chick embryo fibroblasts as observed with glucose labeled with 14C and tritium and with tritium-labeled water. Hoppe Seylers Z Physiol Chem 356, 203-12.



  • Bassham, J. A., Bissell, M. J. and White, R. C. (1974). Quantitative tracer studies of metabolic dynamics of animal cells growing in tissue culture. Anal Biochem 61, 479-91.
  • Dolberg, D. and Bissell, M. J. (1974). Side effects of amphotericin B-deoxycholate (fungizone) and nystatin in chick cells in culture. In Vitro 10, 26-9.
  • Bissell, M. J., Hatie, C., Tischler, A. N. and Calvin, M. (1974). Preferential inhibition of the growth of virus-transformed cells in culture by rifazone-82, a new rifamycin derivative. Proc Natl Acad Sci U S A 71, 2520-4.



  • Bissell, M. J., White, R. C., Hatie, C. and Bassham, J. A. (1973). Dynamics of metabolism of normal and virus-transformed chick cells in culture. Proc Natl Acad Sci U S A 70, 2951-5.



  • Kraft, V., Bissell, M. J. and Gorini, L. (1972). Studies on the mechanism of protein excretion in bacteria: the extracellular proteinase of a Sarcina strain (Coccus P). Hoppe Seylers Z Physiol Chem 353, 1540.
  • Bissell, M. J., Hatie, C. and Rubin, H. (1972). Patterns of glucose metabolism in normal and virus-transformed chick cells in tissue culture. J Natl Cancer Inst 49, 555-65.



  • Bissell, M. J., Rubin, H. and Hatie, C. (1971a). Leakage as the source of overgrowth stimulating activity in Rous sarcoma transformed cultures. Exp Cell Res 68, 404-10.
  • Bissell, M. J., Tosi, R. and Gorini, L. (1971b). Mechanism of excretion of a bacterial proteinase: factors controlling accumulation of the extracellular proteinase of a Sarcina strain (Coccus P). J Bacteriol 105, 1099-109.
  • Sarner, N. Z., Bissell, M. J., Di Girolamo, M. and Gorini, L. (1971). Mechanism of excretion of a bacterial proteinase: demonstration of two proteolytic enzymes produced by a Sarcina strain (Coccus P). J Bacteriol 105, 1090-8.



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