November
2, 2001
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November
2, 2001 |
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Joint
Genome Institute Leads Fugu Breakthrough
· Coming: New Flag Pavillion Joint Genome Institute Leads Fugu Breakthrough By David Gilbert Is it sushi, or is it science? This was the question raised a year ago, when an international consortium lead by the DOE Joint Genome Institute (JGI) set out to “fish out” the genetic code from the deadly delicacy known as Fugu rubripes, the Japanese pufferfish. Humans and puffers are separated by more than 400 million years on the evolutionary tree, but we have more in common than meets the eye. Says one member of the research team responsible for the newly minted draft genome sequence, “both pufferfish and humans have been known to inflate themselves in response to stressful situations.”
Beyond the similarities between fish and our fellow LBNLers — both possess brains, kidneys, immune systems, and other organs in common — there are startling parallels below the surface, at the gross level of gene regulation. In fact, Fugu carries essentially the same genes and regulatory sequences as humans, but it has compressed that information into just 365 million As, Ts, Cs, and Gs — the chemical units or nucleotide bases of DNA — as compared to the 3 billion that make up the human genome. “Fugu is just like the human genome, but at a steep discount — the Reader’s Digest version,” says Sidney Brenner, the two time winner of the prestigious Lasker Award, who took up the molecular genetic study of Fugu a dozen years ago. The 74-year-old scientist’s years of hard work were validated last Thursday at the 13th International Genome Sequencing and Analysis Conference in San Diego. There, Brenner and his colleagues announced that a draft sequence, including nearly six separate iterations of the Fugu genome, was now posted freely on the web — confirming that there is in fact enough science in the fish to sustain a community of researchers engaged in comparative genomics. Brenner’s fame stems in part from being the “godfather” of model organisms, having had a pioneering role in establishing C. elegans (a worm) as an object of keen scientific inquiry. “In enticing us to sequence Fugu, Sydney made us an offer that we couldn’t refuse,” said Trevor Hawkins, director of the JGI and head of the Lab’s Genomics Division. Brenner planted the seed of sequencing Fugu back in 1989 when Hawkins was a graduate student in a lab across the hall from Brenner’s in Cambridge, England. His interest in Brenner’s fishy proposition was rekindled last year when Life Sciences Division Director Mina Bissell invited Brenner to speak at a West Coast Genomics colloquium hosted by the Lab. Shortly thereafter, in Nov-ember 2000, a consortium was formed that rose to take the bait, with JGI and the Singapore Biomedical Research Council’s Institute for Molecular and Cell Biology in the lead. The MRC UK Human Genome Mapping Resource Centre in Cambridge, England, the Cambridge University Department of Oncology, and the Institute for Systems Biology in Seattle, Washington, assumed roles in the consortium, as did two U.S. companies, Celera Genomics and Myriad Genetics. The Fugu draft represents the first vertebrate sequence made available since the momentous Human Genome Project. It is also the first public assembly of an animal genome by the whole genome shotgun sequencing method. “When Celera used the whole genome shotgun approach to sequence the human, fly and mouse genomes, it became clear that this was the most cost-effective and direct method for sequencing large genomes,” says Dan Rokhsar, JGI’s associate director for computational genomics. Although the shotgun method is more efficient, they found it more computationally demanding. “We took up the challenge to reassemble the genome by putting together nearly four million overlapping fragments — in the same way that you’d put together a giant jigsaw puzzle,” Rokhsar said. Key to solving this puzzle was JAZZ, a new algorithm developed at JGI. JAZZ takes advantage of the fact that the sequence fragments are generated in pairs and the pair relationship must be preserved in the final assembly. Also, fragments overlap each other. Superimposed on these facts are the further complications of sequence errors and the riddling of repeated elements throughout the genome. All have to be precisely routed and placed in the puzzle. Rokhsar said that the effort of two graduate students, Nik Putnam and Jarrod Chapman of the Physical Biosciences Division, was critical to the development of JAZZ. Coupled with the Lab’s own National Energy Research Scientific Computing Center (NERSC)—JAZZ is now helping divine the so-called “jewels in the junk.” There are conventional, protein-coding genes that contain the instructions for making transcription factors — proteins that bind to the DNA and control when and where genes are turned on and off. These proteins are often well conserved among rather diverse organisms over evolutionary time. Then there are DNA sequences that the transcription factors bind — so-called cis-regulatory DNA. “These sequences are buried within the part of the genome that has been called ‘junk’ because it had no obvious function,”Rokhsar continues. “Unlike protein coding sequences, cis-regulatory sequences are not well understood. We hope that by comparing the ‘junk’ from Fugu and human that we can identify many more of these regulatory sequences.” A publication on the Fugu sequence assembly is expected before the end of the year. Then the JGI will set out to sequence the microorganism that coexists in many Fugu tissues and harbors the tetrodotoxin that makes an imprecisely prepared Fugu sushi indulgence a deadly liability. This toxin is 1,200 times deadlier than cyanide. One puffer contains enough poison to kill 30 people. Everything else you might want to know about the fabulous
Fugu can be found at the JGI’s Fugu Fun Facts site: http://www.jgi.doe.gov/fugu.
New Clue to How Viruses Infect Cells
By Lynn Yarris In a development that holds ramifications for gene therapy and infection-fighting drugs, a research collaboration led by Carlos Bustamante of the Physical Biosciences Division (PBD) has discovered the mechanism by which at least some viruses infect the cells of other organisms with their DNA. The mechanism involves one of the most powerful biomolecular motors ever observed. “This motor pulls with about 57 to 60 piconewtons of force, which — scaled up to human dimensions — would be enough to lift six aircraft carriers,” says Bustamante, a biophysicist who holds a joint appointment with PBD and UC Berkeley, and is also a Howard Hughes Medical Institute (HHMI) investigator. Biomolecular motors are proteins that undergo shape changes to generate force or torque. Acting like tiny engines, biomolecular motors come in a wide assortment of varieties and perform a broad range of tasks, many involving movement and transportation. One such task is the packing of the coiled lengths of DNA into the protective external shell, or “capsid,” of a number of viruses, including those that cause herpes, chicken pox and shingles. The biomolecular motor that Bustamante and his colleagues observed is the portal motor for the bacteriophage ø29 (phi-29), a virus that infects and destroys soil bacteria and is considered an excellent model system for studying viral assembly. “The portal motor for bacteriophage ø29 compresses the DNA 6,000 times its normal volume,” says Bustamante. “This generates an internal pressure of about 60 atmospheres, which is about 10 times that in a champagne bottle.” Bustamante and his colleagues propose that just as the internal pressure in a champagne bottle will pop a champagne cork, so, too, does the even greater internal pressure inside the bacteriophage’s capsid forcibly inject the viral DNA into an attacked cell. Viruses cannot “live” or reproduce without getting inside a living cell, whether it’s a plant, animal or a bacterium. In the case of ø29, the bacteriophage attaches itself to and introduces its DNA into a soil bacterium, which, unlike the virus, can reproduce on its own. The viral DNA takes over the bacterium’s reproductive programming and instructs it to reproduce copies of the virus instead. So many copies of the virus are replicated that the bacterium ultimately bursts open, unleashing a mass of new viruses ready to infect other bacteria. “Understanding how this DNA packing process works could help us design better drugs to interfere with the packing part of the infection cycle of the virus and perhaps halt infection,” Bustamante says. “It might also be used in gene therapy as a means of transporting new genetic material into cells.” The results of this research were reported in the Oct. 18 issue Nature. Coauthoring the paper with Bustamante were Doug Smith, now with UC San Diego; Sander Tans, now at the Institute for Atomic and Molecular Physics in Amsterdam; UC Berkeley’s Steven Smith; and Shelley Grimes and Dwight Anderson of the University of Minnesota. “I would like to emphasize the close collaboration between my laboratory and that of Dwight Anderson that made possible this work,” says Bustamante. “It was only because of the excellent complementary expertise of the two laboratories that this phase of the work was successfully completed.” To measure the strength of bacteriophage ø29’s portal motor, the research team used a unique force-measuring “optical tweezers” setup that was built in Bustamante’s laboratory by Steve Smith. Working with capsids that were only partially packed with DNA before the packing process was stalled, the researchers tethered the unpacked end of the DNA and the capsid into which it was being packed between a pair of micron-sized polystyrene beads. While the capsid-attached bead was held in place by a pipette, the DNA-attached bead was captured by the optical tweezers — a laser beam that can be used to grasp and move the beads. In the presence of adenosine triphosphate (ATP), the fuel that powers many biomolecular motors, the researchers were able to observe viral DNA packing activity in real time and measure the force being applied by bacteriophage ø29’s biomolecular motor. This enabled them to calculate the total amount of work involved, the total internal pressure on the DNA, and the amount of potential energy available for ejecting the DNA out of the capsid and into a bacterium during infection. “The 57 to 60 piconewtons we calculated as the maximum pull exerted by this motor is an enormous force,” Bustamante said. “The question is, then, what happens to all the work done on the DNA during packing? We claim the energy gets stored up inside the head of the bacteriophage and becomes available to initiate rapid injection of the DNA during the next infection phase.” Bustamante and his colleagues next want to answer some fundamental questions about bacteriophage ø29’s portal motor, such as whether it is a new class of rotary biomolecular motor, one that can couple rotation to DNA translocation. Says UCSD’s Doug Smith, “The motor, consisting of a 10-nanometer-diameter ring of RNA molecules sandwiched between two protein rings, is very intriguing and different from other motors that have been studied. We suspect that rotation of the rings may pull the double helical DNA through the portal, similar to the way a rotating nut can pull on a bolt.” This work was funded by DOE, the National Institutes of Health, and the National Science Foundation.
Coming: New Flag Pavillion
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Because of Currents’ holiday schedule adjustment, the calendar of the next issue (Nov. 16) will cover the period through Dec. 7.
Physicist John Marburger III, director of Brookhaven National Laboratory (BNL), has been confirmed by the U.S. Senate as director of the White House Office of Science and Technology Policy. In that capacity, he will also serve as the science advisor to President George W. Bush.
“I approach this opportunity and profound responsibility with a mixture of humility and immense pride,” Marburger told Senators during his confirmation hearing. “Humility in the wake of the distinguished American scientists who have gone before me, pride in this nation’s unmatched scientific establishment. Science and technology have long provided us with increased security, better health, and greater economic opportunity, and will continue to do so for many generations to come.”
Bush nominated Marburger to be the nation’s top scientific post in June, but the Senate did not take up the nomination for consideration until two weeks ago. When nominated, Marburger was director of BNL and on a leave of absence from the State University of New York at Stony Brook, where he served as president from 1980 to 1994 and as a professor of physics and electrical engineering from 1994 to 1997. In addition to directing BNL, Marburger was also president of the Brookhaven Science Associates (BSA), the partnership between SUNY and Battelle that manages and operates BNL for the U.S. Department of Energy.
During his confirmation hearing, Marburger expressed solid support for the Administration’s position that scientific research should now reflect the heightened concern for national security.
“While I believe we should seek to excel in all scientific disciplines, we must still choose among the multitudes of possible research programs. We must decide which ones to launch, encourage, and enhance and which ones to modify, reevaluate, or redirect in keeping with our national needs and capabilities,” Marburger said. “Today the most pressing of these needs is an adequate and coordinated response to the vicious and destructive terrorist attacks on September 11, a response in which science and technology are already playing an important role. The scientific and technical communities have signaled their commitment to this urgent national need.”
Marburger holds a B.A. in physics from Princeton University (1962) and a Ph.D. in applied physics from Stanford University (1967). Throughout the 1970s, he was on the faculty of the University of Southern California. From 1976 to 1980, he served as the Dean of USC’s College of Letters, Arts and Sciences. A specialist in nonlinear optics, he cofounded USC’s Center for Laser Studies.
During his tenure at BNL, Marburger oversaw the construction and startup of the Relativistic Heavy Ion Collider, the world’s newest and largest particle accelerator for nuclear physics research. He also won praise for his successful work with the Long Island community in the wake of a reactor leak.
BNL has announced that Peter Paul, currently the deputy director for science and technology, will serve as that lab’s interim director until a successor to Marburger is named by the BSA. — Lynn Yarris
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Graham Fleming, director of Berkeley Lab’s Physical Biosciences Division and a professor of chemistry at UC Berkeley, has been awarded the 2002 Earle K. Plyler Prize for Molecular Spectroscopy, given annually by the American Physical Society (APS). The award cites Fleming’s “seminal work on chemical reaction dynamics in liquids and the dynamics of fundamental biological processes using femtosecond laser spectroscopy.”
Fleming’s research concentrates on dynamical processes in liquids, solutions, and other complex systems, notably proteins. He and his colleagues are seeking to provide a molecular-level description of the role of solvents in chemical reactions, which they study on the ultra-short, femtosecond time scale (a femtosecond is a quadrillionth of a second). Their work has led to major advances in the understanding of photosynthetic processes in plants and bacteria.
The Plyler Prize, endowed by the George E. Crouch Foundation of Georgia, was established in 1976 to recognize and encourage notable contributions to the field of molecular spectroscopy. Previous winners have included numerous luminaries, such as George Pimentel and Nobel Prize winners Charles Townes and Ahmed Zewail. In addition to a certificate and cash prize, travel expenses are provided to the APS meeting, at which the prize is presented. Fleming will receive the award at the March APS meeting in Indianapolis.
For more about Fleming’s research, visit http://www.cchem.berkeley.edu/~grfgrp/.
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Carlos Bustamante, head of the Advanced Microscopies Department in the Physical Biosciences Division and a professor of biochemistry at UC Berkeley, has been awarded the APS’s Biological Physics Prize. Presented biennially, the 2002 award cites Bustamante’s “pioneering work in single molecule biophysics and the elucidation of the forces involved in DNA replication and transcription.”
Bustamante, a Howard Hughes Medical Institute investigator, studies the mechanical properties of proteins and nucleic acids, including the structural bases of protein-DNA interactions and the dynamics of DNA-binding “molecular motors” such as enzymes. To this end he and his colleagues develop and use a variety of tools and methods, many of them novel, including optical tweezers, magnetic beads, single-molecule fluorescence, and scanning force microscopy. Their observations have provided new insights into such mechanisms as the means by which viruses can inject their DNA into cells, and how genetic expression in cells may be regulated.
The APS Biological Physics Prize, established in 1981, is sponsored by leading manufacturers of instruments used in biological physics research. Bustamante’s award is the 13th given; first awarded in 1982, the prize was given annually through 1987, then reestablished after a hiatus on a biennial basis. It includes a cash award and certificate, plus travel to the APS meeting.
For more about Carlos Bustamante’s research, visit http://alice.berkeley.edu/.
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On a recent visit to Berkeley Lab, Department of Energy Under Secretary Robert G. Card (center) was shown the EUV (extreme ultraviolet) Lithography Metrology beamline at the Advanced Light Source, part of a Virtual National Laboratory to create a new generation of superdense electronic circuitry through lithography with extremely short wavelengths. Berkeley Lab’s Director Charles Shank (left) and Keith Jackson (right) of the Center for X-Ray Optics, which operates the facility, explained the potential contributions of the new technology to industry and national security, while ALS Experimental Systems Group Leader Howard Padmore and DOE Principal Deputy Administrator Robert W. Kuckuck look on.
The Virtual National Laboratory is a consortium that
brings together the facilities and expertise of Berkeley Lab, Sandia-California,
and Lawrence Livermore National Laboratories with private-industry partners
Intel, Motorola, Advanced Micro Devices, Micron Technology, Infineon Technologies,
and IBM.
In 1999 Michael Barnett of Berkeley Lab’s Physics Division received an email from Nils Ringertz, head of the Nobel e–Museum, the Nobel Foundation’s new website, asking for advice in designing an educational site.
Physicist friends of Ringertz had been impressed by the Particle Adventure website created under Barnett’s direction. The challenge of the Nobel site was to teach physics while providing a context for the contributions of Nobel winners.
With educator Andria Erzberger and Lincoln Sanders (now with the Physics Division, then an undergraduate) Barnett outlined units on topics from fundamental forces to cosmology. Ringertz immediately approved the plan, and Barnett suggested various parties who might build the components. But, he says, “We volunteered to do the quarks ourselves, because that was one of the complicated sections.”
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Ringertz and Per Carlson of the Nobel Foundation visited Berkeley Lab and other U.S. institutions, and when the quark files, with Sanders’s illustrations and animations, were well along, Barnett got a surprise invitation to attend the 1999 Nobel Prize ceremonies.
Last month the Barnett group’s “Structure of Matter”
became the first installment of the physics education site to appear on
the Nobel e–Museum — just in time for the 100th anniversary celebration
of the Nobel Prizes themselves.
To visit the site, go straight to the “Structure of Matter”
at http://www.nobel.se/physics/educational/matter/index.html,
or visit the Nobel e-Museum’s home page at http://www.nobel.se.
¾ Paul
Preuss
Berkeley Lab Director Charles Shank has announced the awards for the FY 2002 Laboratory Directed Research and Development (LDRD) program (see Currents for March 9, 2001). A total of about $10.4 million in operating and capital equipment for 74 projects was allocated, from 140 proposals submitted requesting $24.5 million. The proposals were evaluated in a review process that used the scientific judgment and priorities of division reviews and the Director’s review committees.
In making the awards, Director Shank said, “The proposals
submitted under the LDRD program continue to reflect the exceptional creativity
and innovation of our scientists. There were numerous proposals I would
have liked to fund, and the proposals funded will play an essential role
in fostering initiatives and collaborations that support and advance the
Laboratory and the Department of Energy’s missions. As has happened numerous
times in the LDRD program, I believe many of these current projects have
the potential for significant contributions in their respective scientific
disciplines.”
Lead P.I. , Title , Award ($K)
Akbari, Development of Cool Colored Shingles, 100
Alivisatos et al., Novel Liquid Crystal Phases, 200
Apte, Miniaturized Systems for Particle Exposure Assessment, 100
Bailey, Experimental Mathematician’s Toolkit, 100
Banfield, Microbial Controls on Metals in the Environment, 150
Barcellos-Hoff, Quantitative Spatial and Temporal Resolution of Multicellular
Interactions, 180
Barenblatt, Nonlinear Mathematical Models of Phenomena Related to Petroleum
Mining and Geological Engineering, 95
Bedaque, Effective Field Theory and Few-Nucleon Systems, 100
Benner, Fast Lipoprotein Identification Process, 100
Bertozzi, Synthesis of Novel Tough Materials Based on the Concept of Artificial
Bone, 90
Bethel, Infrastructure for Improving Protein Structure Predication in
Computational Biology, 150
Biegon, PET Ligands for the NMDA Receptor Channel, 75
Biggin, High Sensitivity in vivo Crosslinking Method, 100
Booth, Disorder and Multiple Length Scales in Non-Fermi Liquid f-electron
Intermetallics, 100
Canning, Louie, Computational Methods for Electronic
Structure Codes in Materials Science (Ground State and Excited State Properties),
175
Chakraborty et al., Cooperative Effects Determining Fidelity in Cellular
Recognition, 70
Chemla, Condensation of Indirect Excitons in Coupled Quantum Well Nanostructures,
40
Colella, Ryne, Advanced Simulation of Complex Beam Systems, 150
Corlett et al., An Ultra-fast X-ray Source for f-sec Dynamics, 500
Davis, Nanoscale Electronic Phase Separation: A New Paradigm
for Complex Electronic Materials, 100
Dernburg, Dynamic Reorganization of Chromosome Architecture During Meiosis,
250
Ding, New Machine Learning and Data Mining Methods for Genomics and Information
Retrieval, 115
Dubón, Surfactant Mediated Epitaxy of IV-IV Compounds: Expanding the Limits of Alloy Composition and,
Nanostructure Synthesis with Pb Overlayers, 75
Earnest, Molecular Recognition and Protein/Protein Interactions
in Signal Transduction, 200
Eisen, Analytical Tools for Gene Expression and Genome Sequence, 250
Fadley, Howells, Holographic Imaging with X-rays: Fluorescence and Fourier Transform Holography,
80
Fisk, Indoor Bioaerosol Detection and Quantification by PCR, 90
Francis, Self-assembling Arrays of Nanocrystals Templated by Cytoskeletal
Proteins, 90
Glaeser, Teraflop Challenges in Single-Particle Electron
Crystallography, 230
Gough et al., Large, Patterned Networks of Living Neurons, 130
Gould, Development of a Neutral Molecule Synchrotron Storage Ring, 140
Grcar, Numerical Simulation of Fuel Cells, 160
Hansen, Microprojectile Accelerator for Targeted Biological
Transformation, 80
Hargrove, High Performance System Area Network for PC Clusters, 150
Harris et al., Investigation of Charge Transfer in Organic Electronics
Using Ultrafast
Spectroscopy and Targeted Synthesis, 125
Hazen, Aerobic Bioremediation of Landfills, 200
Head-Gordon, Novel Synchrotron Experiments to Determine Hydration Forces
for Molten Globules and, Model Proteins for Extremophiles, 100
Hinchliffe, Modeling of High Energy Physics Detectors, 95
Hussain et al., Study of Bulk Electronic Structure of Strongly Correlated
Quantum Systems (Manganites), by Using a Novel Momentum-resolved Emission
Soft X-ray Spectrometer, 80
Jap, Structural Studies of Presenilin-1, a Membrane Protein
Critical to the Onset of Alzheimer’s Disease, 80
Jensen, Atomic Scale Modeling of Materials Chemistry, 100
Kuriyan, Allosteric Mechanisms in Proteins Involved in Cell Signaling, 250
Larabell, Tracking Proteins in Light and Soft X-ray Microscopy,
100
Lee, Vetter, Design of Digital Signal Processing Electronics for High
Resolution Detectors, 200
Lee, Spieler, POLARBEAR: An Experiment to Measure Polarization Anisotropy
in the Cosmic Microwave Background, 100
Leemans et al., Novel Coherent THz and IR Source Using a Laser Wakefield
Accelerator and Applications, 225
Leung et al., Compact Coaxial D-D Neutron Generator and Moderator Research,
250
Levi, Perlmutter, Foundations for a SuperNova Acceleration Probe, 600
Li, Suitability of Alternative Architectures for Scientific Computing
in the NERSC-5 Time Frame, 150
Malladi, Segmentation of Mammary Gland Ductal Structure
Using Geometric Methods, 90
Manga, Coupling of Seismologic and Hydrologic Processes, 50
Marletta, Orphan Guanylate Cylase Receptors in C. Elegans, 200
Martin et al., Development of a Far-IR Synchrotron Radiation Source at
the ALS, 230
Mendell et al., Health Effects of Indoor and Outdoor Particle Concentrations,
Assessed with Epidemiology and, Molecular Biology, 150
Mian, Systems Biology: Biological Input-Output Devices, 245
Muller, Second-order Methods for Solid-Fluid Shock Coupling with Application
to Martian Meteorites, 100
Neumark, Photoionization Experiments on Atoms and Molecules Adsorbed Onto Helium Droplets, 100
Ogletree, Investigation of High-Pressure Surface Reactions
With a Molecular Beam of Reaction Products, 75
Oldenburg, Development of Monitoring Strategies for Carbon Sequestration
Verification Using Coupled Subsurface and, Subaerial Simulation, 100
Otoo, Adaptive File Replication and Coordinated Transfer for Data Intensive
Grid Application, 100
Padmore et al., Spatially Resolved X-ray Absorption and
Diffraction Applied to Problems in Environmental Science, 150
Padmore et al., High Pressure Research at the ALS, 150
Pinar, Combinatorial Algorithms in Scientific Computing, 100
Raymond, Development of Highly Selective Catalysis in
Supramolecular Nanoscale Reaction Vessels, 80
Rescigno, Scalable Methods for Studying Collisional Breakup and Rearrangement
Processes, 110
Riley et al., Applying a Coupled Climate-Land Surface Regional Model to
Deduce Trends in Soil Moisture from Air Temperature Data, 160
Schenkel, Solid State Quantum Computer Development with
Single Ion Implantation, 100
Scholl, P-sec Time-Resolved Photo-Electron Emission Microscopy on Magnetic
Nano-Structures, 80
Turner, Synchrotron and Wiggler Radiation Measurement of the Longitudinal Bunch Distribution in Hadron Colliders, 200
Van Hove, Bonding In Low-Dimensional Structures: Theory and Computation, 90
Waychunas et al., Reactivity of Nanoparticles in Natural Environments, 200
Zettl, Synthesis and Control of Molecular Machines, 100
Zolotorev, Source of the Far Infrared Radiation Based on a Material with
an Optically Switched Permittivity, 30
TOTAL: $10,360
Identifying and selecting appropriate breast cancer treatment options can be as daunting as the disease itself. Alternatives to conventional chemotherapy, radiation, and surgery range from folkloric to fantastic in the true sense of the word. Women seeking more options have turned to changes in diet, infusions of megavitamins, teas, herbs, shark’s cartilage and other concoctions to ward off the progression of cancer.
The question remains—do any of these really work?
To imbue the discussion with a sense of balance, on Wednesday, November 14th, the Breast Cancer Research Awareness Forum will resume with the fourth in the series entitled “East Meets West: Alternative Breast Cancer Therapies.” The session will bring together Debu Tripathy, M.D., of the UCSF Carol Franc Buck Breast Care Center, at the University of California at San Francisco and Isaac Cohen, L.Ac., of the American Acupuncture Center in Berkeley, to explore their perspectives on unconventional yet effective treatments for breast cancer. The Forum will be held at noon in the 50 Auditorium.
It is anticipated that within the next two weeks, the three previous installments of the Forum will be available by streaming video at the Forum website: http://www.lbl.gov/lifesciences/BCancer/
For those who would prefer to view a VHS copy of a past
Forum, videotapes are available through Video Services at extension 4237,
or via e-mail, av@lbl.gov.
By
Allan Chen
 Eric Page, Mayor Shirley Dean, Michael Siminovitch and David McGraw at the Berkeley Lamp ceremony. Photo by Ted Gartner |
The energy-efficient Berkeley Lamp developed by scientists here is now saving the City of Berkeley some good money, according to measurements made by Environmental Energy Technologies Division (EETD) researchers and the city’s Energy Office.
The announcement was made at an Oct. 30 ceremony marking the donation of Berkeley Lamps to the city. The event was attended by Berkeley Mayor Shirley Dean, City Manager Weldon Rucker, City Energy Officer Neal De Snoo, the Lab’s Acting Public Affairs Director David McGraw, as well as the lamp’s developers — Michael Siminovitch and Erik Page of EETD.
Mayor Dean called the lamp “quite impressive,” and said that “it is enormously gratifying that [Berkeley Lab], a great public resource, is working with the city” to help to reduce its energy bill. City Manager Rucker, acting as master of ceremonies at the event, praised the Lab’s cooperation with the City.
McGraw thanked the mayor and the city manager ”for giving us this opportunity to inaugurate a new era in our relationship with the City of Berkeley.”
The Berkeley Lamp combines energy efficiency with high quality lighting, using two fully dimmable compact fluorescent lights, specially designed optics, and separate light switches to provide room illumination through both “uplight” and “downlight” (table) illumination.
The ceremony was held in the lobby of the building housing the city’s Engineering Office, across the street from the Berkeley Civic Center. A large, open office area housing city engineers has been “re-lamped” by the lighting researchers. The 2,200-square-foot space has very little natural light. Thirteen Berkeley Lamps and a pair of compact fluorescent torchieres (also developed by the Berkeley Lab group) have replaced the room’s overhead lighting.
“The lamps have reduced peak demand by 50 percent, and kilowatt-hour consumption by nearly 60 percent, saving $915 per year in this room,” said De Snoo during a tour of the retrofitted facility. Prior to the retrofit, the space used about 30 kwh/day of energy and 2500 watts of power. “After the retrofit, the space uses a little more than 10 kwh/day for lighting, and we have cut peak power use in half. We have also reduced carbon emissions from the burning of fossil fuels from six tons of carbon dioxide per year to 2.5 tons,” he said.
De Snoo added that the city will make these lamps available
to Berkeley residents through its energy-efficient purchasing program,
in addition to installing more of them in city offices. “By early next
year, you’ll be able to buy these at the Berkeley Farmer’s Market,” he
said.
By
Monica Friedlander
In the wake of the September 11 tragedy, the nation responded with great generosity, and blood banks everywhere benefited from a huge influx of donors. For the time being Bay Area hospitals do not need to rely on shipments from other regions, according to the Red Cross.
“But this blood supply is far too fragile,” says Kimberly Roberts, communications supervisor for the Northern California region of the Red Cross. “We don’t want to again have to rely on other regions to collect more than they need in order to send it to the Bay Area.”
 Shown here donating at the last blood drive held at Berkeley Lab are Charlotte Bochra (left) and Connie Grondona (right), both from Health Services. |
Roberts says that the need of every patient requiring a transfusion is as great as that of the victims of the terrorist attack.
“Bay Area residents are very capable and willing to donate blood when they know there is a need,” she says, adding “everyday there is a need.”
A two-day blood drive is being held at Berkeley Lab on Nov. 14 and 15 — from 8 a.m. to 4 p.m. on Wednesday and 7 a.m. to 4 p.m. on Thursday in Building 70A, Room 3377. Donors are encouraged to schedule appointments on the BeADonor website (http://www.beadonor.com/). (Use company/group code “LBL” on the web form.) To be eligible, donors must be in good health, at least 17 years old, weigh at least 110 pounds, and not have donated blood in the last 56 days.
Participants in the blood drive will be asked to fill out an anonymous form indicating their division, and the division with the largest percentage of participation will be recognized.
Flu shots are being offered on Nov. 15, but there is no cause for blood donor deferral as long as recipients of the shots have no flu-like symptoms afterwards.
“Patients in hospitals every day rely on receiving blood to survive, ”Roberts says, “Cancer patients, burn victims, accident victims, sickle cell patients and surgery patients are just a few of those who rely on the generosity of blood donors.”
For additional information contact Charlotte Bochra at
X4268.
By
Lisa Gonzales
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Why should I contribute? Who benefits? Where does my contribution go? And what options do I have for donating?
As SHARES — Berkeley Lab’s annual charitable giving campaign — begins its fourth year, these questions are important considerations. This year, employees will be able to get some of the answers at three presentations being held over the next two weeks.
Featured will be representatives from the American Red Cross (Nov. 2) and from two organizations chosen by the Lab for their special compatibility with Berkeley Lab’s missions in science and education: the Chabot Space & Science Center (Nov. 7), and the Lawrence Hall of Science (Nov. 13).
The presentations will be held in the Building 50 auditorium from 12 to 1 p.m.
The Lawrence Hall of Science (LHS) is a science resource center for students, educators, and the general public. LHS provides interactive exhibits and activities that engage children and families while stimulating their fascination with science and exploration. It also develops model programs for use in the classroom.
“Individual donations are crucial to expanding our outreach efforts and increasing the scholarship funds that make our science programs accessible to all children,” said Barbara Ando from LHS.
An example of the cutting-edge work being done at LHS is “Forces That Shape the Bay” — a permanent outdoor exhibit that will depict San Francisco Bay’s geologic evolution. This $2.5 million project is due to open in the summer of 2002. For more information about LHS, visit http://www.lhs.berkeley.edu/.
The Chabot Space and Science Center (CSSC) is a teaching and learning center that focuses on astronomy and the space sciences. Its observatory, planetarium, exhibits, and natural park setting is the continuation and expansion of a public observatory that has served the Bay Area with astronomy and science education programs for over 115 years.
CSSC consists of an 86,000-square-foot science and technology education facility on a 13-acre site in the Oakland Hills. Community support helps fund projects such as the afterschool “Galaxy Explorers,” in which young adults from the Oakland area receive training and paid internships to explain concepts in astronomy, space and science to the more than 200,000 yearly visitors to CSSC. For more details, visit http://www.chabotspace.org/.
Those who wish to contribute elsewhere may pick from a wide variety of nonprofit agencies described in the SHARES packet or at http://www.lbl.gov/shares/. If your favorite charity is not listed, you can still donate through the “Donor Choice Plan” option on the donor form as long as the agency is designated as a tax-exempt IRS 501(c)(3).
“Our goal is to make it rewarding and simple for every employee to find a community organization to support, either with a one-time donation or monthly payroll deductions,” said Karen Ramarino, coordinator of this year’s SHARES campaign. “With so many worthy choices available, we think that everyone here can find a good reason to participate.”
The official campaign is scheduled to conclude on Wednesday,
November 21.
Travel News Flash: United Airlines Schedule Change
The Travel Office has announced that United Airlines is implementing the biggest overhaul it has ever made to its flight schedule.
The changes are part of the effort to cut costs and match service to a severely reduced passenger demand. According to United, 90 percent of advance reservations for passengers traveling between Oct 31 and Jan 7 will be affected, and some customers’ itineraries may be changed more than once. United anticipates that most people will depart within 90 minutes of their scheduled times. Passengers who booked non-stop flights and are forced to make a stopover, or those whose reservations were changed to departures more than 90 minutes before or after their scheduled times will be offered the option of a refund.
Travelers who have booked their reservations using Travel Power will receive an automatic e-mail notification of any changes to their itinerary. Travelers are encouraged to confirm their itineraries prior to departure. Itineraries can be viewed on http://www.virtuallythere.com/.
Tickets do not need to be reissued to reflect the new
schedule. The original paper or e-ticket receipt is proof of purchase,
and boarding passes with the correct flight information will be issued
at check-in. United has also joined other major airline carriers in announcing
sharp reductions in in-flight meal service.
Employee Referral Incentive
Program a Big Success
The U.S. Department of Energy recently notified the Lab of their approval to extend and expand the Employee Referral Incentive Program (ERIP) through Jan. 31, 2003. This pilot award program, rolled out this past February, was created as a strategy to enhance recruitment efforts and encourage Lab employees to utilize their existing contacts and networks as potential sources for qualified candidates.
The DOE originally approved ERIP as a one-year pilot program from Feb. 1, 2001 to Jan. 30, 2002. Given the success of the program, Berkeley Lab submitted a request to DOE to extend it for an additional year. In addition to granting the request, the DOE also approved expanding the program to include ERIP eligibility for referrals leading to hires in postdoctoral positions, effective Feb. 1, 2002.
Since February, Human Resources received 328 referrals which resulted in 30 hires. People have been hired into positions such as administrative assistants and specialists, budget analysts, financial analysts, scientific engineering associates, computer systems engineers, health and safety technicians, bus and truck drivers, and others.
To make a referral, complete an ERIP referral form and send it with the resume to employeereferral@lbl.gov or via Lab mail to ERIP Coordinator at MS 937-600. The employee referral must be submitted to the ERIP Coordinator (not just to the hiring supervisor) to ensure eligibility for an award. The referral must also be submitted in a timely manner, before the referral has been interviewed or a job offered. The referral form and additional information can be found on the HR website at http://www.lbl/.gov/ Workplace/HumanResources/ERIP/index_erip.html.
More details and updates on the program will be forthcoming
in future issues of Currents.
Share Science
Month at LHS.
The Lawrence Hall of Science invites all UC employees
to “share science” with a child during the month November. With a UC ID
card, an employee and one child will be admitted free. In addition to
the many usual attractions, two major exhibits are featured right now:
“Scream Machines: the Science of Roller Coasters,” and “A-Maze-ing Maze”
— a chance to test your sense of direction negotiating your way out of
LHS’s own maze constructed out of colorful 8-foot-tall panels and measuring
35 ft x 35 ft.
Holiday Crafts Fair
The sixth annual Berkeley Lab Craft Fair will be held on Wednesday, Nov. 14 from 3 to 6 p.m. in the Lab cafeteria. Featured will be works from talented Lab artists and craftspeople. Everyone is invited and can participate in free drawings. A toy, food and coat drive for local charities will also be held at the same time.
Also, don’t forget to pick up your copy of the LBNL Benefit Cookbook. Proceeds from sales of the book will go to the September 11, 2001 Fund.
The Craft Fair is sponsored by the Employees Activities
Association. For more information contact Shelley Worsham at X6123 or
AWorsham@lbl.gov.
Community Relations Office Seeks New Tour Guides
It happens every year at this time. Students complete their dissertations and promising young scientists are hired away, leaving in their wake vacancies in Berkeley Lab’s visitor outreach program. Ritesh Agarwal is off to Harvard and Artur Braun to the University of Kentucky. Earlier, Mark Baertschy moved to the University of Colorado and Andreas Schumacher to Infineon, a Siemens spin-off in Munich.
“The experience of public speaking gave me a great start for my new job in Colorado,” said Baertschy of his work as a tour guide.
Guides receive $70 for each two-hour tour of the Lab’s facilities. After a one-hour training session, guides are prepared to give the public of all ages a glimpse of the world of science at Berkeley Lab. They talk about the Lab’s history and get the chance to share their own research with a typical group of 10 to 15 people. The Lab sponsors public and group tours most Friday mornings.
Interested graduate and undergraduate students and post-docs
may contact Terry Powell in the Community Relations Office (X4387, tpowell@lbl.gov)
or visit the office in Building 50A, Room 4117.
Christmas Revels Tickets
The Employees’ Art Council (EAC) has reserved a block of tickets for the sixteenth season of the Christmas Revels, to be held at the Scottish Rite Theater in Oakland. Discounted tickets for the 5 p.m. performance on Saturday, Dec. 15. are $20 each for adults and $13 for children (under 12) and seniors (65 and over).
These discounted tickets are available only through EAC by contacting Mary Clary at X4940, MMClary@lbl.gov. The deadline for reservations and payment is Friday, Nov. 15.
The Christmas Revels celebrates the holiday season with
unique form of musical theater that incorporates music, dance and drama.
The Revels productions build on universal themes drawn from the myths
and rituals of varied cultures to celebrate the Solstice Season. This
theme for this year’s show is Ireland around 1905, with emigrants bound
for the U.S. More than 80 local singers, dancers, actors and children
will perform.
Travel News Flash: United Airlines Schedule Change
The Travel Office has announced that United Airlines is implementing the biggest overhaul it has ever made to its flight schedule.
The changes are part of the effort to cut costs and match service to a severely reduced passenger demand. According to United, 90 percent of advance reservations for passengers traveling between Oct 31 and Jan 7 will be affected, and some customers’ itineraries may be changed more than once. United anticipates that most people will depart within 90 minutes of their scheduled times. Passengers who booked non-stop flights and are forced to make a stopover, or those whose reservations were changed to departures more than 90 minutes before or after their scheduled times will be offered the option of a refund.
Travelers who have booked their reservations using Travel Power will receive an automatic e-mail notification of any changes to their itinerary. Travelers are encouraged to confirm their itineraries prior to departure. Itineraries can be viewed on http://www.virtuallythere.com/.
Tickets do not need to be reissued to reflect the new schedule. The original paper or e-ticket receipt is proof of purchase, and boarding passes with the correct flight information will be issued at check-in. United has also joined other major airline carriers in announcing sharp reductions in in-flight meal service.
Employee Referral Incentive Program a Big Success
The U.S. Department of Energy recently notified the Lab of their approval to extend and expand the Employee Referral Incentive Program (ERIP) through Jan. 31, 2003. This pilot award program, rolled out this past February, was created as a strategy to enhance recruitment efforts and encourage Lab employees to utilize their existing contacts and networks as potential sources for qualified candidates.
The DOE originally approved ERIP as a one-year pilot program from Feb. 1, 2001 to Jan. 30, 2002. Given the success of the program, Berkeley Lab submitted a request to DOE to extend it for an additional year. In addition to granting the request, the DOE also approved expanding the program to include ERIP eligibility for referrals leading to hires in postdoctoral positions, effective Feb. 1, 2002.
Since February, Human Resources received 328 referrals which resulted in 30 hires. People have been hired into positions such as administrative assistants and specialists, budget analysts, financial analysts, scientific engineering associates, computer systems engineers, health and safety technicians, bus and truck drivers, and others.
To make a referral, complete an ERIP referral form and send it with the resume to employeereferral@lbl.gov or via Lab mail to ERIP Coordinator at MS 937-600. The employee referral must be submitted to the ERIP Coordinator (not just to the hiring supervisor) to ensure eligibility for an award. The referral must also be submitted in a timely manner, before the referral has been interviewed or a job offered. The referral form and additional information can be found on the HR website at http://www.lbl.gov/Workplace/HumanResources/ERIP/index_erip.html.
More details and updates on the program will be forthcoming
in future issues of Currents.
Share Science Month at LHS
The Lawrence Hall of Science invites all UC employees
to “share science” with a child during the month November. With a UC ID
card, an employee and one child will be admitted free. In addition to
the many usual attractions, two major exhibits are featured right now:
“Scream Machines: the Science of Roller Coasters,” and “A-Maze-ing Maze”
— a chance to test your sense of direction negotiating your way out of
LHS’s own maze constructed out of colorful 8-foot-tall panels and measuring
35 ft x 35 ft.
Runaround Results Available on the Web
Full results of the Berkeley Lab Runaround, held on Oct. 12, are now available in PDF format on the Runaround website at http://cfi.lbl.gov/~derenzo/runaround/.
The results are broken down by age group and gender. Results of previous years’ races (1980-2000) are also available on this site.
 |
Berkeley Lab’s Washington DC office held its own Runaround
on Oct. 12, with a few friends from other offices joining in for the fun.
Left to right are, back row: Satish Kumar, Vestal Tutterow, Rob Hitchcock,
Anthony Radspieler, Jr., Mary Jo Ibanez, Kate Bannan (UCOP), Phil Coleman,
Lucas Frances (UCOP), Meggen Watt (PNNL), Wavery Brown (PNNL), Jennifer
Hawkins (Georgetown University), and Moira Howard-Jeweler—with a couple
of very young participants in the double jogger, Zoe and Daphne Jeweler.
Front row, left to right, are MichelleWare and Jaeden Ware (in stroller),
Ian McGrory (in stroller), Laura Van Wie, Maria Merritt, and Stuart Chaitkin.
SHARES SPEAKER: AMERICAN RED CROSS
1 p.m., Bldg. 50 auditorium
FIDELITY INVESTMENT BRIEFING
1 p.m. Bldg. 50A-5132
SHARES SPEAKER: CHABOT SPACE & SCIENCE CENTER
1 p.m., Bldg. 50 auditorium
FLU SHOT CLINIC
8 a.m. – 12 p.m., Bldg 26
NATIVE AMERICAN MONTH FILM SCREENING: A CLASS DIVIDED
12 – 1 p.m., Bldg. 50 auditorium
SHARES SPEAKER: LAWRENCE HALL OF SCIENCE
12 – 1 p.m., Bldg. 50 auditorium
BREAST CANCER RESEARCH AWARENESS FORUM: “EAST MEETS WEST: ALTERNATIVE BREAST CANCER
THERAPIES”
12 – 1 p.m., Bldg. 50 auditorium
EAA 6TH ANNUAL HOLIDAY CRAFT FAIR
3 – 6 p.m., cafeteria
BLOOD DRIVE
8 a.m. – 4 p.m., Bldg. 70A-3377
BLOOD DRIVE
7 a.m. – 4 p.m., Bldg. 70A-3377
FLU SHOT CLINIC
8 a.m. – 12 p.m., Bldg 26
NATIVE AMERICAN MONTH SPECIAL PRESENTATION: “LATINO
YOUTH AND EDUCATION”
12 – 1 p.m., Bldg. 50 auditorium
Send us your announcements
Announcements for the General Calendar and Bulletin Board
page may be sent to MSFriedlander@lbl.gov. Seminar & Lectures items
may be mailed to currents_calendar@lbl.gov. You may also fax items to
X6641 or mail them to Bldg. 65B. The deadline for the Nov. 16 issue—which
covers the period through Dec. 7—is 5 p.m. Monday, Nov. 12.
DEPARTMENT OF PHYSICS COLLOQUIUM
What We Have Learned from COMPTEL and What We Expect from INTEGRAL
Speaker: Volker Schönfelder, Max-Planck Institut
4:30 p.m., 1 Le Conte Hall
JOINT NSD/PHYSICS COLLOQUIUM
The Electron-Ion Collider (EIC): A New Microscope to Study Hadron Structure
Speaker: Richard G. Milner, Bates Linear Accelerator Center
10 a.m., Bldg. 50 auditorium
BERKELEY SPECTROSCOPY CLUB SEMINAR
Advances in Photoelectron Diffraction and Holography
Speaker: Michel van Hove, Materials Sciences Division
10 a.m., Bldg. 6, Room 2202
SURFACE SCIENCE AND CATALYSIS SEMINAR
Surface Science in the Real World: More Than Just a Monolayer
Speaker: Larry DuBois, Stanford Research Institute
1:30 p.m., Bldg. 62, Room 203
PHYSICS DIVISON RESEARCH PROGRESS MEETING
Charm Production at HERA-B
Speaker: Denis Dujmic, University of Texas
4 p.m., Bldg. 50A, Room 5132
SURFACE SCIENCE AND CATALYSIS SEMINAR
Studies on Molecular Level Interface Structures of Polymers in Contact
with Different Media
Speaker: Zhan Chen, University of Michigan
1:30 p.m., Bldg. 62, Room 203
ENVIRONMENTAL ENERGY TECHNOLOGIES DIVISION SEMINAR
Gateways, Meters and Demand Response: Opportunity or Folly
Speaker: Roger Levy, Levy Associates
Noon, Bldg. 90, Room 3148
PHYSICS DIVISON RESEARCH PROGRESS MEETING
Research Progress at AUGER
Speaker: Carlos Escobar, UNICAMP, Brazil
4 p.m., Bldg. 50A, Room 5132
AIM, a Walnut Creek-based computer software training
firm, provides onsite PC computer courses to Lab employees.
|
Date |
Course |
Price |
|
11/5 |
Dreamweaver 3.0 Fundamentals |
$300 |
|
11/6 |
FileMaker Pro 5.0/5.5 Intermediate |
$150 |
|
11/7 |
Excel 97 Intermediate |
$150 |
|
11/9 |
HTML Programming Level I |
$225 |
|
11/15 |
PowerPoint 97 Intermediate/Advanced |
$150 |
|
11/26 |
HTML Programming Level II |
$225 |
|
12/4 |
Word 97 Advanced |
$150 |
|
12/5 |
Dreamweaver 3.0 Intermediate/Advanced |
$300 |
|
12/12 |
Excel 97 Advanced |
$150 |
|
12/14 |
FileMaker Pro 5.0/5.5 Advanced |
$150 |
All in-house courses are taught on PCs with Windows 98®. The 97 series programs are used by the newest version of Microsoft Office for Windows 98®.
For users of a Mac 6.x series or an older Mac or PC version,
the material covered in these courses will be applicable.
Note: The desks in the Bldg. 51L computer training
room were recently replaced with ergonomically enhanced workstations.
‘99 TOYOTA CAMRY LE, 4 dr, dk green, 16.7K mi, at, V6 3.0L eng, pwr win/locks/seats, dual air bags, am/fm/cass/CD, sliding sunrf, exc cond, single owner, $18,000, Ilham, X7001, 368-4765
‘99 COUGAR, V6, metallic red, 44.6K mi, pwr seat/win, am/fm/ cass, great cond, $10,450/bo, Shraddha, (925) 286-2215, 724-9870
‘96 PLYMOUTH NEON w/ Thule roof rack, <45K mi, pwr win/ locks, dual air bags, am/fm/cass, ac, metallic red, good cond, $5,000/bo, Leslie, X4007
‘93 NISSAN PATHFINDER, 4 wd, 14K mi, exc cond, runs & looks like new, at, ac, am/fm/cass, 8-spkr system, red ext w/ grey int, $9,900/bo, Peter, 525-3290
‘92 HONDA ACCORD LX sedan, 4 dr, red ext w/ grey int, 5 spd, ac, am/fm/cass, all pwr, single owner, 134K mi, new clutch, 2 yr old tires & battery, all maint on schedule, 30 mpg/town, 33-35/ hwy, very good cond, $5,500, Mickie, 430-1736
‘91 MAZDA 626 LE, silver, sunrf, 5 spd, 80K mi, single owner, $4,500/bo, Fred, X4892, Susan, 841-3552
‘90 NISSAN 240SX, 2 dr fastback, at, ac, pwr steer/breaks, cruise, CD player, tilt, alloy wheels, 135K mi, rebuilt trans in past 6 mos, new tires & battery, looks & runs great, $2,900/bo, Diana, X4070, (916) 564-0655
‘87 FORD BRONCO II, 130K mi, single owner, all maint records, ext fair cond but mech very sound & runs very well, asking $2,500, Fred, X4352, 524-4138
‘85 HONDA CIVIC 2 dr hatch, tan w/ black trim, 121K mi, 38 mpg, new tires, body a bit worn but mech sound, runs great, reliable, great commute car, $1,200/ bo, Diane, X5839, 658-9690
‘78 VOLVO 4 dr sedan, new tires, radio, well maint, records avail, good commute car, $750/bo, John, X5307, 841-7875
ALBANY house share: looking for female, vegetarian, non-smoker, exc location at 827 Cornell Ave, $625/mo incl util, Laurie, 526-4134, Fred, X4352
CENTRAL BERKELEY nice furn rooms, $300/wk or $930/mo, kitchen, laundry, TV, DSL avail, walk to shuttle & shops, rm avail 12/5, Jin or Paul, 845-5959, jin.young@juno.com, Paul, X7363
EL CERRITO, room avail in 2 bdrm 1-1/2 bth apt, avail for 5-6 mos starting 1/1/02, furn for extra $15/mo, lge liv rm, balcony, dw, covered parking space, w/d in bldg, close to BART and shopping, no smoking/pets, $610/mo+ util, Alysia, 495-2467, admarino@ socrates.berkeley.edu
HAYWARD, 2 bdrm/1 bth house, Mission Blvd, walk to BART, completely remodeled, available 11/1, first/last/dep, $1,500/mo, Shelley, X6123
NORTH BERKELEY, near Fat Apple's (MLK & Rose), comfortable furn rm in gracious old house, exc neighborhood (close to library, parks, recreation, shopping & bus), pleasant & peaceful non-smoking household, avail 11/16, $575/mo incl util + $200 dep, Ljuda, 643-8277, 527-1331
NORTH BERKELEY, cozy 2 bdrm in Monterey Market area, priv backyard, $1,550/mo, first/last/ dep, Lyn, 524-5570
SAN PABLO room avail in priv home starting 11/1, share kitchen, bath, liv rm, sun rm, garden, deck, $700/mo incl util, Carmen, (650) 756-2401
PhD STUDENT seeking studio/ 1bdrm, considerate, mature non-smoker from the business school, very reliable, would be great for families who need a reg house/pet sitter, Barbara, 643-1423, bukhvalo@haas.berkeley. edu
OAK TV/STEREO unit, glass & wood doors, 61"w x 52"h x 21"d, $250, Todd, X2897, (925) 962-3957
TYVEK CAR COVER, size 3 for autos 14'3" - 16'8" in length, never used, in original box, $30; older digital answ machine, works fine, $5; Apple Newton 2000 MessagePad upgraded to 2100 w/ keyboard, 2 MB backup card, 28k modem, software, rechargeable batteries, connection cables, works great, $100, Jon, X5974
STORAGE SPACE, lge (10x20), secure, clean, dry storage in a garage avail 12/1 in El Cerrito near Central & San Pablo, no vehicles or workshop, $175/mo, Nancy, X5102
MOUNTAIN BIKE Cannondale M700, Manitou fork, 20" frame, incl 2nd set of wheels, $500, John, 290-5054
SOUTH LAKE TAHOE, spacious chalet in Tyrol area, close to Heavenly, fully furn, peek of the lake from the front porch, sleeps 8+, sunny deck, pool/spa in club house, close to casinos, other attractions, $150/day+$75 one-time cleaning fee, Angela, X7712, Pat/ Maria, 724-9450
BLACK & DECKER microwave espresso maker w/ sep glass
milk frother, $20 value, Kathy, X4931
Ads are accepted only from LBNL employees, retirees, and onsite DOE personnel. Only items of your own personal property may be offered for sale.
Submissions must include name, affiliation, extension, and home phone number. Ads must be submitted in writing via e-mail (fleamarket@lbl.gov), fax (X6641), or delivered/mailed to Bldg. 65B.
Ads run one issue only unless resubmitted, and are repeated only as space permits. They may not be retracted once submitted for publication.
The deadline for the Nov. 16 issue Thursday, Nov. 8.
