Today at Berkeley Lab nameplate Berkeley Lab
Monday, August 30, 2004

Rubin Scores Big Again with NIH Grant Renewal

Berkeley Lab Genomics Division head and Joint Genome Institute Director Eddy Rubin and a team of collaborators have secured a four-year, $11.6 million National Institutes of Health (NIH) grant renewal to accelerate the development of and facilitate access to comparative genomics tools for heart, lung and blood research. These methods specifically focus on deciphering biomedically relevant features in the human genome.

“Eddy Rubin’s Comparative Genomic Resources program represents the crème de la crème of the National Heart Lung and Blood Institute-supported genomic programs,” said Stephen Young, senior investigator, Gladstone Institute of Cardiovascular Disease and professor of medicine at the University of California, San Francisco. “Eddy’s program had the perspicacity to visualize the enormous relevance of comparative sequence data, and then had the vision and drive and creativity to develop the tools that make it possible for any laboratory to mine comparative sequence data. Along the way, they have uncovered a treasure trove of important biological discoveries, including never-recognized gene regulatory regions and entirely new genes involved in lipid and lipoprotein metabolism.”

Among the many major accomplishments of the prior funding cycle was the development of VISTA (Visualization Tools for Alignments), an extremely popular suite of comparative genomic tools that has garnered accolades throughout the genomics community for its ability to quickly compare genomes of various organisms. VISTA was also among the winners of the 2003 Federal Laboratory Consortium Awards for Excellence in Technology Transfer.

In the next funding cycle, the group, consisting of collaborators from UC Berkeley, UC Davis, UCSF, Children’s Hospital Oakland Research Institute, Stanford and others, will continue to develop new user-friendly comparative genomic tools, as well as continue to multi-faceted education and outreach program for the cardiovascular disease research community. Other key elements of the program include projects to assess gene regulatory elements identified by cross-species sequence comparisons and clinical resequencing to examine large sets of candidate genes suspected to cause heart, lung and blood disorders.

Berkeley Lab leads all DOE national laboratories in NIH funding with over some $44 million in fiscal year 2003 and ranks in the top 3 percent of all NIH-funded organizations.

Back to "Today at Berkeley Lab"

DOE logo Office of Science logo UC logo