The following program-project scale project, in addition to many other projects not listed here, is based within the Genome Dynamics Department.
NIH modENCODE Projects "Model Organism ENCyclopedia of DNA Elements /Center for Excellence in Functional Genomics"
The goal of these projects is to identify the functional elements in the genomes of the of the model organisms of the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans. The projects are part of the ENCODE program (Encyclopedia of DNA Elements) administered by the National Human Genome Research Institute (NHGRI). modENCODE projects conducted in the Life Sciences Division are:
- "Comprehensive Characterization of the Drosophila Transcriptome": Focused on the identification of sequence-based functional elements associated with transcribed sequences including both protein coding and non-protein coding sequences, specifically characterizing gene structures including transcription start sites (TSS), polyadenylation sites, alternative transcripts and the motifs that regulate splicing. Principal Investigator: Susan Celniker
- "Genome-wide Mapping of Chromosomal Proteins in Drosophila": Focused on determining the 'landscape' of Drosophila proteins associated with chromatin across the entire genome. Principal Investigator: Gary Karpen (Karpen Lab)
- "Identification of DNA Elements Governing Chromatin Function in C. elegans": Focused on the identification of discrete elements that regulate chromatin structure and function. This project involves researchers from eight institutions in four countries and is led by Principal Investigator Jason Lieb of the University of North Carolina. co-Principal Investigator: Abby Dernburg
- "A Data Coordinating Center for modENCODE": The modENCODE project is a key sequel to the sequencing of the fly and worm genomes, and will have an enormous impact on our understanding of biological processes in all higher eukaryotes, including human. In order to manage the diverse, large-scale datasets that will be produced by modENCODE, the data coordinating center (DCC) tracks the data being produced in the 37 different modENCODE laboratories, integrates it with other information sources, and makes it available to the research community. This project brings together four groups from three countries led by Principal Investigator Lincoln Stein at the Ontario Institute of Cancer Research. co-Principal Investigator: Suzanna Lewis
modENCODE website: http://www.genome.gov/ENCODE/ / http://www.modencode.org/
In the News: http://www.lbl.gov/Science-Articles/Archive/LSD-modENCODE.html