Organisms express their genomes in a cell-specific, context-dependent manner, resulting in a variety of cellular phenotypes. Mapping cellular responses to genomic data or comparatively analyzing cellular responses requires detailed quantitative analysis in context. The Imaging and Informatics Lab has developed computational and bioinformatics systems for (i) high content screening of multicellular responses, and (ii) association of genomic data with physiological responses. Our current efforts focus on developing new imaging modules for direct imaging of gene expression, developing technologies for improved understanding of the microenvironment stress for tumor development, and identifying the mechanism of signaling networks through dynamic analysis of drug transport at multiple scales. The Imaging and Informatics Lab web site can be found at http://vision.lbl.gov.