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Jagust Lab

Research Interest

Research in my lab is aimed at understanding the structural, functional and biochemical basis of brain aging and neurodegenerative diseases associated with brain aging.  We use techniques of positron emission tomography (PET), magnetic resonance imaging (MRI), functional MRI, and neuropsychology and cognitive neuroscience to study normal older people, and patients with neurodegenerative disorders of Alzheimer's disease and related dementias and Parkinson's disease.  Studies are using PET imaging to detect the deposition of brain amyloid, and we are also looking at how changes in neurotransmitters are related to behavioral changes in aging.  Our goals include early detection of Alzheimer-related changes with PET and MRI scanning, using imaging to track treatments in both Alzheimer's and Parkinson's disease, and understanding the fundamental mechanisms of cognitive change in the aging brain.

Selected Publications

Landau SM, Lal R, O’Neil, JP, Baker S, Jagust WJ.  Striatal dopamine and working memory. Cerebral Cortex. In press.

Rabinovici GD, Jagust WJ, Furst AJ, Ogar JM, Racine CA, Mormino EC, O’Neil JP, Lal RA, Dronkers NF, Miller BL, Gorno-Tempini ML.  A? amyloid and glucose metabolism in three variants of primary progressive aphasia.  Annals of Neurology, In press.

Eberling JL, Jagust WJ, Christine CW, Starr P, Larson P, Bankiewicz KS, Aminoff MJ.  Results from a phase I safety trial of hAADC gene therapy for Parkinson’s disease.  Neurology, 70:1980-1983, 2008.

Cools R, Gibbs SE, Miyakawa A, Jagust W, D’Esposito M.  Working memory capacity predicts dopamine synthesis capacity in the human striatum. Journal of Neuroscience, 28:1208-1212, 2008.

Jagust WJ, Zheng L, Harvey DJ, Mack WJ, Vinters HV, Weiner MW, Ellis WG, Zarow C, Mungas D, Reed BR, Kramer JH, Schuff N, DeCarli C, Chui HC.  Neuropathological basis of MR images in aging and dementia.  Annals of Neurology, 63:72-80, 2008.

Jagust W, Reed B, Mungas D, Ellis W, DeCarli C.  What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia?  Neurology, 69:871-877, 2007.

Rabinovici GD, Furst AJ, O’Neil JP, Racine CA, Mormino EC, Baker SL, Chetty S, Patel P, Pagliaro TA, Klunk WE, Mathis CA, Rosen HJ, Miller BL, Jagust WJ.  11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration.  Neurology, 68:1205-1212, 2007.

Sun FT, Schriber RA, Greenia JM, He J, Gitcho A, Jagust WJ.  Automated template-based PET region of interest analyses in the aging brain.  Neuroimage, 34:608-617, 2007.

Jagust WJ, Gitcho A, Sun F, Kuczynski B, Mungas D, Haan M.  Brain imaging evidence of preclinical Alzheimer’s disease in normal aging.  Annals of Neurology, 59:673-681, 2006.

Projects

Jagust

William Jagust

Faculty Senior Scientist/
Life Sciences Division

Department:
Structural Biology and Imaging

Berkeley Lab
One Cyclotron Road
Mailstop: 55R121
Berkeley, CA 94720
Tel: (510) 486-5065
Fax: (510) 486-4768
Email: WJJagust@lbl.gov
Website: Jagust Laboratory
Biosketch: PDF

Professor of Public Health and Neuroscience,
University of California Berkeley

 

Lab Members

Principal Scientist
Jagust, William

Staff Scientist
Eberling, Jamie

Postdoctoral Fellows
Braskie, Meredith
Furst, Ansgar
Landau, Susan
Perrotin, Audrey

Programmer Analyst
Madison, Cindee

Research Associates
Baker, Suzanne
Hayenga, Amynta (Lab Manager)
Yen, Irene

Students
Dang, Linh
Mormino, Beth
Nguyen, Dennis
Sossong, Tony
Steed, Tyler
Rostami, Ara

Visiting Scholar
Rabinovici, Gil

Administrator
Roach, Matisse