The recent determination of the genomic sequences
of yeast, nematodes, fruit flies, mice, and humans is a watershed
The Genome Biology Department is focused
to take advantage of this wealth of new information. It is well
known that DNA encodes the basic blue print of life, but it is
not known how to interpret most of this information, particularly
that from animals with large genomes. To address this issue, laboratories
within the department are developing computational, biochemical,
and genetic methods to decipher the complex sequence motifs that
control RNA transcription, DNA replication, and chromosome structure.
In addition, complete genomic sequences open up entirely new ways
to study human disease, the control of animal development, and
complex macromolecular process such as meiosis. New techniques
allow changes in the activity of all genes to be monitored simultaneously.
Many groups within the department are using these methods to address
a range of questions. We believe that the data from such system-wide
analyses will fundamentally alter the way we think about most
problems in biology.
Members of the Genome Biology Department also
participate in: NHLBI's Programs
for Genomic Applications project
(PGA), DOE's Joint
Genome Institute (JGI), the
Berkeley Drosophila Genome Project (BDGP), and the
Berkeley Program in Genomics, a program in which over 30 groups
from LBNL and the University of California at Berkeley collaborate
in a joint graduate program, seminar series, and annual retreat.
We also make use of the outstanding engineering and computational
resources at LBNL, such as the Bioinstrumentation
Group and National
Energy Research Scientific Computing Center (NERSC).