The characterization and analysis of genome sequences from such diverse organisms as humans to the most primitive soil microbe represent a watershed opportunity for biology. The Genomics Division is taking advantage of this wealth of new information. While it is well known that DNA encodes the basic blue print of life, it is not known how best to interpret most of this information. To address this question, laboratories within the division are developing computational, biochemical, genetic, and imaging methods to decipher the complex sequence motifs that control RNA transcription, DNA replication, and chromosome structure. The Division is also home to Berkeley Lab's complement of the workforce that makes up the U.S. Department of Energy Joint Genome Institute (JGI). JGI is committed to advancing genomics in support of DOE missions related to clean energy generation and environmental characterization and cleanup. JGI, headquartered in Walnut Creek, Calif., provides integrated high-throughput sequencing and computational analysis that enable systems-based scientific approaches to these challenges.