As head of the Genome Sciences Department at Berkeley Lab, Dr. Edward Rubin's task is to try to make sense of the data coming from the Human Genome Project. This national effort to decipher the human genetic code will eventually acquire enough data to fill 200 Manhattan telephone directories. The value of this work will be determined by scientists' ability to convert sequence data into information relevant to human biology and disease. Dr. Rubin's work over the years on heart disease, Down Syndrome and sickle cell anemia has focused on using genetically engineered mice containing human genes as a test tube to derive insights into the genetic basis of these human conditions.