|Berkeley Lab Model Tracks Indoor Anthrax Dispersal|
|Contact: Dan Krotz, firstname.lastname@example.org|
It took three fumigations spanning three months to rid the Hart Senate Office Building of anthrax after a single contaminated letter was sent to Senator Tom Daschle last October.
Although the epicenter of the $14 million cleanup was Daschle's office, the nine-story building was sealed after traces of anthrax were found in other rooms. No one knows precisely how the aerosolized spores drifted from the envelope to the far corners of the building, but Berkeley Lab researchers are zeroing in on an understanding.
"We've always included aerosol behavior in our modeling and experimental work, but the seed crystal was what happened in the Hart Building," says Richard Sextro, of the Indoor Environment Department in the Environmental Energy Technologies Division. "It became very clear that one of the big unknowns is what happens after you open the envelope. Where does the anthrax go?"
The indoor anthrax model developed by Sextro and colleagues David Lorenzetti, Tracy Thatcher, and Mike Sohn had its origins in the Department of Energy's Chemical and Biological National Security Program, initiated in 1997. The program initially included only Lawrence Livermore and Los Alamos laboratories' work on outdoor modeling of biological and chemical attacks. However, because Berkeley Lab's Indoor Environment Department has one of the nation's most comprehensive indoor air programs, Joan Daisey (the late head of the department) successfully pitched a proposal to DOE in 1998 for funding to explore chemical and biological agent dispersion in buildings. A fourth DOE lab, Argonne, rounds out the program by modeling subway contamination.
Sextro and his colleagues have developed a model with a singular purpose: to track the fate of airborne anthrax spores and use these simulations to estimate exposures. Their rationale is based on the unnerving fact that one gram of anthrax contains 100 billion spores, and only 10,000 spores are needed to spur a lethal case of inhalation anthrax. This also means nearly every spore counts, so the model has to be robust enough to depict anthrax dispersal in considerable detail.
To start, the team used information obtained from Indoor Environment
Department experiments that studied aerosol transport and deposition in
both rooms and ducts. In addition, a multizone building airflow model
developed in part by Berkeley Lab scientists was used to simulate the
room-to-room airflows that can potentially transport anthrax spores between
However, most airflow models do not account for the activities of people. What happens when someone steps in anthrax that has settled on the floor and tracks it from room to room? Or resuspends it into the air by simply walking on the floor? To explore this poorly understood component of anthrax dispersion, the modeling team incorporated terms that describe foot traffic's influence on deposition and suspension. Delving deeper, they subdivided surfaces into two types: accessible areassurfaces on which people can walk and unwittingly disturb deposited anthraxand inaccessible areas comprised of hard-to-get-to surfaces like corners and behind desks; once anthrax settles in such places, it typically isn't tracked or resuspended. These additional variables enable the model to more fully map the chain of events that affect anthrax dispersal.
"This pushes us, conceptually, into a new area of knowing what happens to particles on accessible surfaces where they can be resuspended or tracked," Sextro says. "This is important, because by examining anthrax dispersal in as complete a picture as possible, we determine where we need to focus our research."
So far, the model has been unleashed in a hypothetical, computer-generated, 190-square-meter office floor, subdivided into a main hallway surrounded by six offices, each occupied by one person. A letter carrying one gram of anthrax is opened in one room. Some anthrax remains in the envelope, some settles on the floor, and some disperses into the air. Several scenarios are played out. In one, everyone remains in their office and the HVAC system is the sole means of dispersal. In more complex scenarios, people move from room to room and track, resuspend, and redeposit anthrax throughout the office floor.
Disturbingly, in even the simple scenario, everyone exceeds or comes close to receiving a lethal dose.
Although the model is still under development and is primarily a research tool, Sextro believes it can eventually be used to map real-world exposure cases. "It's very important to know how much anthrax is in the HVAC system, on the floor, and on the backside of ceiling tiles," Sextro says. "In addition to the important task of estimating potential exposures, andultimatelyhow to avoid high exposures, the model can help focus decontamination efforts by determining where anthrax accumulates."