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Berkeley Lab Currents

August 16, 1996



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Biomedical Isotope Facility opens its doors for research

Lynn Yarris

During the week-long celebration of Berkeley Lab's 65th Anniversary, scheduled to begin Aug. 26, there will be another event to chronicle. On Friday, Aug. 30, the Laboratory will dedicate the newest member of its family of facilities--the Biomedical Isotope Facility.

Begining in the 1930s, when John Lawrence (brother of Lab-founder Ernest) and his associates discovered that certain radioactive isotopes could be safely used in biomedical research, Berkeley Lab has evolved into a world leader in the field of biomedical imaging. Much of this research depends upon the use of special radioisotopes that disappear quickly from the human body.

What makes a biomedical radioisotope safe is its short half-life--the time it takes for half of a given amount of the material to decay into a non-radioactive product. A short half-life means that the radioisotope can be sent through an organ or tissue and "traced" or detected to yield an image with no side effects.

"Radiotracers follow along, they don't play," explains Henry VanBrocklin, a Life Sciences Division chemist with the Center for Functional Imaging (CFI). VanBrocklin heads the Biomedical Isotope Facility and oversaw its construction. "The idea of a radiotracer is to image the physiology without perturbing it."

The short half-lives that make biomedical isotopes safe for humans also require these isotopes to be used soon after they are produced, or else they are gone. One common production technique, which Berkeley Lab researchers helped develop, is the "generator method," in which long-lived "parent" isotopes continually decay into short-lived "daughter" isotopes that can be extracted as needed. However, there are important radioisotopes that can only be produced in cyclotrons or reactors.

During the 1980s, Berkeley Lab researchers obtained these special radioisotopes from the 88-Inch Cyclotron. However, since this machine was built for nuclear physics research, procuring time to produce biomedical isotopes was difficult and costly. More recently, such isotopes have been obtained from nearby sites off the Hill, such as UC Davis and its Crocker Cyclotron. The short half-lives of the isotopes, however, make their transportation over any distance a problem.

Even 10 years ago, CFI's head, Thomas Budinger, saw the advantage in producing radioisotopes at Berkeley Lab in a dedicated facility. He initiated the process that led to construction of the Biomedical Isotope Facility.

"Ironically, though the cyclotron was invented here, we (CFI) did not have the dedicated small cyclotron our competitors around the world had," he says. "I am very happy that this new facility is now here and performing beautifully. The instrument and facility are a credit to the laboratory staff who made it happen."

The centerpiece of the Biomedical Isotope Facility, which is located adjacent to Bldg. 55, is a room-sized cyclotron built for Berkeley Lab by a commercial company called CTI, headquartered in Knoxville. This mini-cyclotron (the diameter of its magnet is only 90 centimeters) can accelerate negative hydrogen ions to 11 MeV (million electron volts) of energy. Once they attain peak energy, these negative hydrogen ions are sent through a thin carbon foil to strip them of their electrons and convert them into a beam of protons. This proton beam is then directed into a target made up of a specific stable isotope in order to produce a desired radioisotope. (Bombardment with energetic protons causes target nuclei to release alpha particles or neutrons, converting the nuclei to radioisotopes.)

"The system is designed to deliver fluorine-18, oxygen-15, nitrogen-13, and carbon-11," says VanBrocklin. "These are the most common positron-emitting isotopes for radio-pharmaceuticals."

VanBrocklin and his colleagues must work quickly with their radioisotopes. The respective half-lives are 110 minutes for fluorine-18, 20 minutes for carbon-11, 10 minutes for nitrogen-13, and two minutes for oxygen-15.

Before a radioisotope can be used as a tracer, it must first be incorporated into a pharmaceutical compound, a process called "labeling." Fluorine-18, for example, is commonly attached to a type of sugar to form "fluorodeoxyglucose." FDG is especially valuable for studying the chemistry of the brain, the heart, and cancerous tumors. Water labeled with oxygen-15 is an important blood flow tracer, and ammonia labeled with nitrogen-13 is used as a tracer for heart research.

Labeling a pharmaceutical compound entails transferring the isotopes from the cyclotron into a lead-lined glovebox. The cyclotron at the Biomedical Isotope Facility currently holds either gas or liquid targets, which means that the isotopes can be siphoned through tubes directly into the glovebox with no need of human handling.

"We have a collaboration with the Nuclear Science Division to develop solid targets as well," says VanBrocklin. "This would require physical handling of the radioisotopes but it would expand the array of isotopes we can produce."

Once a radiopharmaceutical has been prepared inside a glovebox, it again must be quickly put to use. An underground pneumatic tube system linking the Biomedical Isotope Facility to CFI laboratories in Bldg. 55 can transport radio-pharmaceuticals between the two locations in eight seconds.

"Because we're working with such small quantities of radiopharmaceuticals, a fast and reliable means of transportation is critical," says VanBrocklin.

The radioisotopes produced at the new facility will serve CFI researchers in a variety of ways. VanBrocklin, who also heads CFI's chemistry group, says he and his colleagues will continue their efforts to develop new radioisotopes and biomedical tracers. They are currently working with a fluorine-18 labeled compound called fluorometatyrosine, which shows great potential for the study of Parkinson's disease.

The primary use of the Biomedical Isotope Facility's radioisotopes will be in the CFI's two positron emission tomography (PET) machines. PET is an imaging technique (pioneered in part at Berkeley Lab) whereby the annhilation of radioisotope positrons localized in the body yields photons that can be detected by a ring of crystals. This makes it possible to observe otherwise invisible chemical processes in the human body as they take place.

CFI houses the highest resolution PET scanner in the world, a 600-crystal ring with a spatial resolution of 2.6 millimeters and a patient port that can accommodate a patient's head and neck. It also harbors a 47-layer imaging system which can accommodate the entire body. The addition of the Biomedical Isotope Facility is expected to facilitate CFI's ongoing imaging studies of the brain and heart for Alzheimer's disease and atherosclorosis, as well as its collaborative research into cancer.

VanBrocklin gives credit to several individuals for helping to bring the Biomedical Isotope Facility to Berkeley Lab. In addition to Budinger and Chet Mathis (VanBrocklin's predecessor at the Lab), he also cites chemists Jim O'Neal and Steve Hanrahan from his group.

The Biomedical Isotope Facility dedication ceremonies will be held at 10:30 a.m. on Aug. 30, in the Bldg. 55 parking area, adjacent to the new facility.

CAPTION: Henry VanBrocklin, head of the new Biomedical Isotope Facility, manipulates the mechanical arms of one of the facility's high-tech glove boxes. Rather than reaching into the box through gloves, a researcher simply manipulates the arms. Photo by Roy Kaltschmidt

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65th Anniversary

Opening of new exhibit area to mark beginning of week-long celebration

By Ron Kolb

Historic artifacts from Berkeley Lab's illustrious past will transform the entrance to the Lab's administrative center into an exhibit area when the Laboratory celebrates its 65th Anniversary on Monday, Aug. 26.

At 3 p.m. that day, the Lab community is invited to help dedicate the remodeled Bldg. 50 lobby when it officially opens to the public. Director Charles Shank will cut the ribbon to the display area, and Nobel Laureate Glenn Seaborg will be available to discuss the memorabilia from his collection and to autograph periodic tables of the elements on which seaborgium (element 106) appears. Refreshments will be served from 3 to 5 p.m.

Lapel pins with the seaborgium symbol will be offered for sale, with proceeds going to help support one of Seaborg's favorite education projects, the high school Chemathon competition.

Seaborg's noontime talk and the exhibit opening will highlight the first of five days of activities honoring Berkeley Lab's 65 years of history. Other key events include a discussion featuring former Lab directors David Shirley and Andrew Sessler at noon on Aug. 28 in the Bldg. 50 auditorium; an address by Martha Krebs, head of the DOE's Office of Energy Research, at noon on Aug. 29 in the Bldg. 50 Auditorium; and the dedication of the new Biomedical Isotope Facility, honoring the 100th anniversary of nuclear medicine, at 11 a.m. on Aug. 30.

Almost two dozen significant or unusual items from the Laboratory's archives will be on display in the lobby exhibit, most of them for the first time. They range from founder Ernest Orlando Lawrence's pioneering 4-inch cyclotron from 1930, to Lawrence's original desk, to some of Seaborg's most noteworthy artifacts. Those include the electroscope he used to discover iodine 131 and cobalt 60, his research notebook in which the fissionability of plutonium was first recorded, and a variety of mementoes acknowledging his many awards and honors.

A radiometer that traveled on the COBE satellite and sent scientist George Smoot his dramatic data on cosmic background radiation will be on display, as will an electronic sensor from the Keck Ten-Meter Telescope, which was conceived and designed at Berkeley Lab. Physicist David Nygren's Time Projection Chamber will be represented by one of his early detectors, and Melvin Calvin's seminal work in describing photosynthesis will be recalled by a "lollipop" glass encasing used to study algae.

Other exhibits will pay homage to the Lab's legacy in lighting efficiency research, heavy ion radiosurgery, and, of course, cyclotrons and accelerators. A small-scale prototype of part of the Advanced Light Source vacuum chamber will be mounted on a wall. Luis Alvarez' bubble chambers, invented by Nobelist Donald Glaser to track the paths of charged particles, will have two representatives, one outside the entranceway and a smaller version inside.

The exhibit, though not inclusive of all significant research conducted at Berkeley Lab, will nonetheless capture the spirit of innovation and discovery that has been the hallmark of the scientific work here. One wall will be devoted to a decade-by-decade timeline of achievements, another to Lawrence and his "boys" via historic photos, and a third to Berkeley Lab's nine Nobel Prize winners.

The display will even include one of the two original doors through which Lawrence and colleagues passed at the old "Rad Lab" on the UC Berkeley campus, beginning on Aug. 26, 1931. This door on display is marked "117 Radiation Laboratory"; its companion resides in the Smithsonian Institution in Washington, D.C.

After its anniversary dedication, the exhibit area will be open to the public during normal business hours.

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Lab artifact missing

One piece from a collection of artifacts being prepared for the 65th Anniversary exhibition in the Bldg. 50 lobby has been removed from a secured storage area. The missing item, an historic therapy mask used to protect patients undergoing heavy ion radiation surgery, is official Laboratory property and should be returned. Information about the location of the mask should be given to TEID's Marilee Bailey (X4145), who is mounting the display as part of the Lab's 65th Anniversary celebration.

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DOE's O'Toole endorses Lab's "necessary and sufficient" program

During a visit to the Lab on Aug. 8, Tara O'Toole, DOE Assistant Secretary for Environment, Safety and Health (ES&H), indicated that efforts are being made to move away from the 1970's "compliance approach" to meeting safety requirements and toward new "necessary and sufficient" standards. She believes this trend will accelerate in the future, both in corporate America and around the world.

Berkeley Lab, one of DOE's pioneering sites for developing "necessary and sufficient" standards, is at the forefront of this movement. O'Toole enthusiastically endorsed the program--also called the Work Smart Standards project--which seeks to characterize the work done at the Lab and then apply only those ES&H standards necessary by law and sufficient to mitigate the associated hazards.

O'Toole received a briefing from process leader Ben Feinberg and EH&S Division Director David McGraw, toured the National Tritium Labeling Facility (NTLF) and the Human Genome Center, and participated in a malaria isolation and identification demonstration at the Advanced Light Source.

Berkeley Lab's effort in the area of safety standards builds upon successful pilot projects conducted last year at the NTLF and seven other sites across the DOE system. This will be the first multipurpose laboratory to apply the standards site-wide. According to O'Toole, the refinements developed here should serve as a model for the rest of the DOE.

Dick Nolan, director of DOE's Berkeley Site Office, echoed O'Toole's enthusiasm. He said the cooperative nature of the Work Smart Standards process has promoted a "partnership culture," enhancing communication and coordination between DOE and the Laboratory.

Now that it has taken the first strides in this new era of cooperation and reduced regulatory burden, O'Toole said, the Lab should "get the word out on what we've accomplished."

CAPTION: Tara O'Toole (foreground), DOE Assistant Secretary for Environment, Safety and Health, views a malaria-infected red blood cell during a tour at the Advanced Light Source. With her are (front to back) ALS/EH&S program manager Georgeanna Perdue, EH&S's Jack Bartley, and Ben Feinberg of the ALS.

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New UCSC chancellor to speak at 65th Anniversary dinner

The University of California's newest chancellor, M.R.C. Greenwood of UC Santa Cruz, will be the keynote speaker at Berkeley Lab's 65th Anniversary dinner, to be held at the Laboratory on Thursday, Aug. 29.

Greenwood, a recent nominee to President Clinton's National Science Board, is one of the country's leaders in research policy and scientific program development. A member of the Institute of Medicine of the National Academy of Sciences, she served for two years as associate director for science at the Office of Science and Technology Policy. In that capacity, she advised President Clinton on an array of issues, including budget development for the multi-billion-dollar fundamental science national effort.

Prior to her appointment in July as successor to Karl Pister at Santa Cruz, Greenwood was dean of graduate studies and vice provost for academic outreach at UC Davis, where she also held a dual appointment as professor of nutrition and of internal medicine. She also taught at Vassar College, her alma mater.

The anniversary dinner will be a tribute to Berkeley Lab's 65 years of national service and will feature representatives from the Department of Energy, the University of California, and the Laboratory. It will conclude the annual on-site review of institutional planning by Office of Energy Research Director Martha Krebs and members of her program planning staff.

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N E W S W I R E

DOLE TAX CUT PLAN CALLS FOR ENORMOUS DOE CUTS:

Republican presidential candidate Bob Dole has called for a 15-percent reduction in individual tax rates. To pay for the reduction, he has proposed cutting $32 billion from DOE's budget over the next six years. Though the Dole campaign refused to elaborate on where those cuts would come from, it could at the very least require the elimination of all non-defense programs. Energy Secretary Hazel O'Leary told reporters that Dole's plan would require terminating all of the non-defense national laboratories and shutting down the department's energy efficiency, renewable energy, and fossil energy programs. Spending on the nuclear waste repository program would be cut in half, essentially bringing the program to a halt. "You want another astonishing fact?" O'Leary asked. "Dole's plan will halt all of our work in safety programs, which would not only endanger our own employees, but put our communities at risk and put at risk contamination to our ground water and our drinking water."

POLITICAL BATTLES LOOM OVER FEDERAL R&D SPENDING:

Three of the federal government's top science managers told Congress that they intend to fiercely fight for more money than is penciled into President Clinton's long-term budget projections for their agencies. Though they stopped short of repudiating the White House plan, Martha Krebs, head of DOE's Office of Energy Research, Dan Goldin, NASA administrator, and Neal Lane, director of the National Science Foundation, told Congress that the White House projections should be taken with a grain of salt. Goldin promised "one hell of a fight" to assure adequate funding for NASA and his combative stance was echoed by Krebs and Lane. Republican lawmakers such as House Science Committee chair Robert Walker (R-Pa.) and Sen. Kit Bond (R-Mo.), chair of a panel that oversees funding for NASA and NSF, say that the comments of the three science leaders make it clear that the White House figures are meaningless. Bond called the Administration's projections a "scam" that posits a balanced budget without the pain of slashing programs. Many feel this partisan debate misses a far more ominous point. Noting that the White House plan would slash civilian R&D funding by 19 percent between 1995 and 2002, while the Republican plan would cut such funding 23 percent over the same period, Rep. George Brown (D-Calif.) argues that both plans spell big trouble for U.S. science. "Both the Administration and Republican budgets are declining precipitously," Brown said. "On this scale, they look nearly identical." Rather than debate which of the two plans is better, Brown says, lawmakers should join together to find ways to boost investment by government and industry in science and technology.

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Cyclotron road blocked north of Bldg. 50A next weekend

Due to construction activities at Bldg. 50A on Saturday and Sunday, Aug. 24-25, Cyclotron Road will be blocked off on the north side of the building. Please use the Strawberry Gate for access to buildings east of Bldg. 65. Access through the Strawberry Gate during off hours (5 p.m. to 8 a.m.), will require a card key to open the gate. Blackberry Gate will remain open with limited access to Bldgs. 88 and 65.

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National Science Bowl winners take ALS as first place prize

By Jeffery Kahn

For the winners of the 1996 National Science Bowl competition, Berkeley Lab is the Disneyland of science. The Venice (Calif.) High School team passed up a chance to go to Alaska, instead choosing a week here as their prize for prevailing over 1,700 other teams in the Department of Energy-sponsored competition.

Last week, the five members of the team and their teacher/coach came to Berkeley and the Lab's Advanced Light Source. Kids with a voracious appetite for knowledge, they were given a crash course on the ALS--everything from surveying and tweaking the alignment of beamline components, to CAD design, to doing residual gas analysis of the ultra-high vacuum system. With that foundation of understanding, Thursday evening they became the first high school students to participate in experiments on ALS beamlines.

Why turn down a trip to Alaska's North Slope for an opportunity to learn about wigglers and undulators?

"Because," said senior Chris Mayor, "we're getting a chance to play with a $100 million machine on the cutting-edge of science."

The team's coach and chemistry teacher, Richard Erdman, said that because his kids come from a public high school, not a private college prep institution, they had the underdog mentality going into the Science Bowl competition. Ordinarily, he said, people associate the school with gangs rather than academics. As the competition made clear, that association is not entirely accurate.

The team includes a former Vietnamese refugee, a senior who dropped out of high school three years ago, and a 15-year-old sophomore who attends UCLA part time. Exceptionally motivated, the team taught itself advanced physics when the school lost its physics teacher.

Speaking for a group that regularly studied and prepared until long past midnight, team captain David Dickinson said, "We're just hard-working students." His teammates elaborated on that, saying they all followed one basic training rule: No sleeping allowed.

Several of the students have overcome serious obstacles en route to their Science Bowl victory. My Le Hoang was born in China after her parents sought refuge there after the Vietnam War. She moved to America as a preschooler and now lives with her mother, a seamstress, and father in a flat near Chinatown in Los Angeles. She will enter MIT this fall.

Chris Mayor endured a family crisis three years ago that resulted in his skipping classes and ultimately flunking out. He was about to apply for his high school equivalency degree but re-enrolled at Venice High. This fall, he will be a freshman at UC Berkeley.

During their stay, the students were hosted by ALS technical writers Jane Cross and Liz Moxon, and the staff of the Lab's Center for Science and Engineering Education. Upon their arrival Sunday, team members went to Telegraph Avenue. After that, they chose to spend the rest of their unscheduled time touring the 88-Inch Cyclotron, the National Center for Electron Microscopy, and San Francisco's Exploratorium. They also spent a day at Xerox's Palo Alto Research Center.

Despite their amazing grasp of science, the week's stay was the students' first chance to interact with scientists. Cross said they arrived with a stereotype of a scientist as white, male, bearded, with a British accent, wearing a lab coat and working independently. Berkeley Lab's diversity and collaborative atmosphere considerably broadened their outlook, she said.

Like other team members, Noah Bray-Ali, an incoming senior, had done some homework on the ALS before coming here. "We had some background," he said. "The basic idea of the ALS is getting electrons moving really fast. But there's stuff you don't pick up on the street. If you want to learn photoemission spectroscopy, you have to come here."

Thursday evening the students performed several experiments at the ALS, working with teams involved in ongoing research projects. One group on Beamline 6.1 is imaging the malaria parasite, observing how the structure of red blood cells changes when infected with the parasite. A second project on Beamline 9.3.2 is studying the surface and bulk structure of technologically important materials.

The week concluded with a presentation to ALS staff, during which the team stumped management with questions from the Science Bowl, such as: "What elements are named after towns in Sweden?" Team member Candice Kamachi summed up the team's feelings about their week at Berkeley Lab as "inspirational, and a once in a lifetime experience."

CAPTION: The ALS extends a warm welcome to the winning National Science Bowl Team: (clockwise from upper left) Candice Kamachi, My Le Hoang, Richard Erdman (coach), Chris Mayor, Noah Bray-Ali, and David Dickinson. Photo by Joe Moore

CAPTION: Hands-on science takes on a whole new meaning for students when they have the opportunity to work alongside researchers at the ALS. At Beamline 6.1, the students image malaria infected blood cells using the x-ray transmission microscope.

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Lab offering career development courses

At the Lab's Employee Development Fair held in June, more than 200 employees indicated an interest in the Transitions Management Group (TMG) career development workshops. Through the Employee Development and Training Unit, TMG will offer on-site workshops, including the three described at right.

Each of the three workshops are instructed by professional career consultants with significant corporate experience. The workshops are 1-1/2 hours in length and include interactive exercises, readings, and establishing individual commitments and action plans.

Workshops are $60 per person and require a minimum of 12 participants. Please contact the Employee Development & Training Unit (X5999 or ckbrothers@lbl.gov) by Friday, Aug. 23, if you are interested in attending any of the following workshops:

"You, Inc.: How to Manage Your Career Like a Business"

If you don't take charge of your career, who will? Are you planning strategically? Do you have a clear mission and goal? What's your backup if unexpected change occurs? These discussions and presentations will unleash your creative ideas and generate valuable "next steps" you can take now.

"Networking Strategies: Managing Your `You, Inc.' Board of Directors"

Research shows that informal contacts and relationships are critically important in job performance and career success within increasingly decentralized and responsive organizations. This workshop helps you to increase the power of your alliances as information providers, advisors, and supporters to help you achieve your career goals.

"Making Decisions in a Rapidly Changing Environment"

Don't miss career opportunities created by change. Learn how to seize on options quickly and reduce career risks. Practice a quick and effective tool for making productive career decisions, including when to stay exactly where you are.

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Bowling is down their alley

League members looking for new bowlers

By Monica Friedlander

For some two dozen Lab employees, this is one of the most exciting times of the year: the start of the bowling season, about to get under way on Sept. 4. Bowling League members meet every Wednesday night at the Albany Bowl (540 San Pablo Ave.) for an evening of fun as well as spirited team competition.

But not to worry, says Cynthia Long, the League's secretary/treasurer. You don't have to even know how to keep score to join and have a great time, nor do you need your own equipment.

"There's a misconception that you have to be good to play," she says. "If you can put your fingers on a bowling ball, you can play. It's a simple sport to pick up, and we have all skill levels. Some people do it for fun, others are good enough to turn pro."

The League consists of multiple teams of five players each, which compete against one another. About half the League is made up of Lab employees.

The bowling season is 33 weeks long, September through May, although members do not need to commit to more than half a season if they can find a replacement for the other half. A banquet is held at the end of the season, at which time trophies and prize money are awarded to the winners.

The cost is $13 per night, which covers all fees except shoe rental ($2 extra). The Lab also contributes a small sum to the League, which covers miscellaneous year-end deficits.

"It's the one night a week I really look forward to," says Long, a recreational bowler since she was 12 years old. Her enthusiasm for the sport is contagious. "It's a wonderful opportunity to meet people from other areas in a relaxed setting outside the work environment," she says. "I develop friendships with people, which extend to our work relationship. We work better and have a better rapport. And it breaks the monotony of the daily routine."

The Bowling League will hold a pre-season meeting on Wednesday, Aug. 28, to plan for the year and determine who plays on which team. The meeting will be held at Albany Bowl.

For more information or to join the League, contact Cynthia Long (X6672), Harold Blair (X7685) or Ed Masuoka (X5337).

CAPTION: Bowling League members Ed Masuoka, Harold Blair, and Cynthia Long are looking forward to the new season. Photo by Roy Kaltschmidt

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Berkeley Lab Family Day Picnic

Sunday, Aug. 25 -- WaterWorld USA

Tickets are still available for this year's Berkeley Lab Family Day Picnic, to be held from 10:30 a.m. to 6 p.m. on Sunday, Aug. 25, at WaterWorld USA in Concord.

In addition to all the park's attractions, there will be a barbecue picnic from 12:30 to 2 p.m., and unlimited soft drinks from 11 a.m. to 4 p.m. Tickets are on sale at the cafeteria from 11 a.m. to 1:30 p.m. weekdays. Cost is $17 per person; children 3 and under are admitted free.

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Ergonomics Fair

The Laboratory's Ergonomics Committee is sponsoring an Ergonomics Fair Tuesday through Thursday, Aug. 20-22, in the cafeteria. Representatives of several ergonomic companies will be on hand with samples and demonstrations of ergonomic accessories, furniture, workstations, alternative keyboards, and an assortment of ergonomic tools.

On Thursday, Aug. 22, Terrie Rizzo, international health and fitness educator, will present her "Sittercise" exercise program and discuss workplace wellness. Informational handouts on ergonomic equipment available at the Laboratory, as well as brochures and posters on how to set up an ergonomically correct workstation, will also be available.

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Summer Lecture Series videos available at Library

The talks from the 1996 Summer Lecture Series are now available on video for check-out from the Library in Bldg. 50. They are also included in the Library's online catalog, through which they can be requested electronically, and received via Lab mail. Videos circulate for one week at a time, although they may be renewed if no one else has requested the title.

The speakers and their topics are as follows:

"Geonomics and Berkeley" Mike Palozzolo, Life Sciences Division

"The Year 2000 and Beyond in Large Scale Scientific Computing" William McCurdy, Computing Sciences

"Greenhouse Gas Emissions: Can Policies Make a Difference?" Mark Levine, Energy & Environment Division

"How to Weigh the Universe Using Supernovae" Saul Perlmutter, Physics Division

"Synthetic Membranes: Teaching an Old Polymer New Tricks" Deborah Charych, Materials Sciences Division

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Library training sessions

The Library is offering 15-to-20-minute training sessions on two of its services. The LBNL UnCover Database allows you to obtain faxed articles from journals that the Library does not have. "Electronic Journals" delivers articles to your desktop. The training schedule is listed below. Please contact Jhane Beck, X4622, for more information.

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CALENDAR OF EVENTS -- August 19-30

Calendar of Events at Berkeley Lab

BERKELEY LAB CALENDAR

The Berkeley Lab Calendar is published biweekly here on the World Wide Web and in Currents by the Public Information Department. Employees can list a meeting, class, or event in the Calendar by using this submission form. The deadline for submissions is 5 p.m. on Monday in the week that Currents is published.

In addition to the events listed below, Berkeley Lab's Washington, D.C. Projects office is hosting a Science and Technology Seminars series. 

Scientific Conferences

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MON., AUG. 19

SHOEMOBILE

7:30 a.m. - 4:30 p.m. near Bldg. 77

SURFACE SCIENCE AND CATALYSIS SCIENCE SEMINAR

"The Coking of Acidic Zeolites" will be presented by Jose L. Monteiro of the Federal University of Rio de Janeiro, Brazil, at 1:30 p.m. in the Bldg. 66 Auditorium.

THEORETICAL PHYSICS SEMINAR

"Hadron Spectrum and Quark Masses from Lattice QCD" will be presented by Dr. Rajan Gupta of LANL at 4 p.m. in Bldg. 50A-5132.

ALS/CXRO SEMINAR

"Interface Structural Studies of Thin Film and Multilayers by X-ray Scattering Techniques" will be presented by Cinzia Giannini of P.A.S.T.I.S.-C.N.R.S.M. at 4:10 p.m. in Bldg. 2-100B.

EMPLOYEE MUSIC CLUB

Classical Group Rehearsal, 5-7 p.m. in the cafeteria

TUES., AUG. 20

EH&S CLASS

Adult CPR (EHS 123), 9 a.m.-noon, Bldg. 48-109

LBNL LIBRARY TRAINING SESSION

LBNL UnCover Database will be offered at 3 p.m. in Bldg. 62-339

LIFE SCIENCES DIVISION SEMINAR

"Phosphotyrosine Phosphatases: Regulators of Cell Motility and Adhesion" will be presented by Andrew Stoker of the Royal Society University, Oxford, at 4 p.m. in Bldg. 66-316.

WED., AUG. 21

TOASTMASTERS'

Officer's Meeting at 12:10 p.m. in Bldg. 2-100

SURFACE SCIENCE AND CATALYSIS SCIENCE SEMINAR

"Electrochemical Surface Reconstruction" will be presented by Alexei Kornyshev of Forschungszentrum Juelich (KFA), Germany, at 1:30 p.m. in Bldg. 66-316.

ALS/CXRO SEMINAR

"X-ray Holography with Atomic Resolution" will be presented by M. Tegze and G. Faigel of the Research Institute for Solid State Physics, Budapest, Hungary, at 4:10 p.m. in Bldg. 2-100B.

EMPLOYEE MUSIC CLUB

Folk Group Rehearsal, 5:30-7:30 p.m. in the cafeteria, for info. contact Larry Bell at X5406.

THURS., AUG. 22

LBNL LIBRARY TRAINING SESSION

LBNL UnCover Database, 11 a.m. in Bldg. 50-134

BUILDING ENERGY SEMINAR

"Electric Motor and Belt Retrofits" will be presented by Steve Greenberg of the In-House Energy Management Group at noon in Bldg. 90-3148.

CENTER FOR ENVIRONMENTAL BIOTECHNOLOGY SEMINAR

"Carcenogenicity of Coal Tars: What We Now Know and Why We Need To Know It Now" will be presented by Larry Goldstein of EPRI at noon in Bldg. 50A-5132.

SURFACE SCIENCE AND CATALYSIS SCIENCE SEMINAR

"Electron Microscopy and Hydrocarbon Catalysis: Structure-Activity Correlations Observed on Thin Film Noble Metal Catalysts" will be presented by Konrad Hayek of the University of Innsbruck, Austria, at 1:30 p.m. in the Bldg. 66 Auditorium.

FRI., AUG. 23

OPEN CALENDAR

MON., AUG. 26

EMPLOYEE MUSIC CLUB

Classical Group Rehearsal, 5-7 p.m. in the cafeteria.

TUES., AUG. 27

EH&S CLASS

Compressed Gas Safety (EHS 231), 10:30-11:30 a.m., Bldg. 51-201

LBNL LIBRARY TRAINING SESSION

Electronic Journals, 3 p.m. in Bldg. 62-339

LIFE SCIENCES DIVISION SEMINAR

"Integrins and Proteases in Angiogenesis" will be presented by David J. Cheresh of Scripps Research Institute at 4 p.m. in the Bldg. 66 Auditorium.

WED., AUG. 28

EH&S CLASS

Earthquake Safety (EHS 135), 10-11:30 a.m., Bldg. 48-109

LBNL LIBRARY TRAINING SESSION

Electronic Journals, 11 a.m. in Bldg. 50-134

ALS/CXRO SEMINAR

"Nanowires at Stepped Surfaces" will be presented by Franz Himpsel of the University of Wisconsin at Madison at 4:10 p.m. in Bldg. 2-100B.

EMPLOYEE MUSIC CLUB

Folk Group Rehearsal, 5:30-7:30 p.m. in the cafeteria.

THURS., AUG. 29

EH&S CLASSES

Radiation Protection - Fundamentals (EHS 400), 9 a.m.-noon, Bldg. 51-201

Radiation Protection - Lab Safety (EHS 432), 1-3:30 p.m., Bldg. 51-201

FRI., AUG. 30

OPEN CALENDAR

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Dining Center August 19-23

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F l e a M a r k e t

Flea Market ads may be sent via e-mail to fleamarket@lbl.gov, Fax to X6641, or Lab mail to Bldg. 65B. The deadline is 5 p.m. Friday.

AUTOS/SUPPLIES

'74 JENSEN-HEALEY, w/orig. aluminum Lotus engine, low mi., $3K/b.o. Amy, X6596

'76 MERCEDES BENZ 280, 4-dr, runs well, leaving area, must sell, $1800/b.o. 531-8844

'79 TOYOTA Corolla, 5-spd, AM/FM/cass., 216K mi., $300/offer. Dave, X4024, 526-0552

'80 FORD Fairmont, a/t, 97K mi., 6-cyl, new brakes, starter & battery, AM/FM cass. stereo, clean, leaving country, must sell, $550/b.o. Mimo, X4824, 526-7388 (eve.)

'82 TOYOTA Tercel, 158K mi., a/t, runs very well, well maint., recent brake job, tires, body so-so, $1450/b.o. 741-7732 (eve.)

'84 SUBARU GL, 5-spd, 4-dr, AM/FM cass., clean, new clutch battery & column switch, looks reasonable & runs fine, 163K mi., $1250. Erik, X4174

'84 TOYOTA Tercel 4x4 wgn, runs well, reliable trans., 141K mi., all records. Nick, X7177, 528-3109

'85 CHEVY Sprint, fair cond., standard trans., exc. gas, new tires & clutch, cass./stereo, $1250/b.o. Amy, X6596, 525-5041

'86 HONDA Accord LX, 100K mi., a/t, p/l, p/w, all records for last 2 yrs., $4300/b.o. Sajid, X5184, 548-0641

'86 NISSAN Stanza sta. wgn (minivan style), gd cond., many recently replaced parts, 120K mi., $3K/b.o. Amir, X4125, 528-7876

'86 TOYOTA Celica GT, 5-spd, silver, runs well, very clean, 1 owner, all records, a/c, AM/FM/cass., cloth seats, 112K mi., $3500. Bob, X6557, 527-6937

'87 HONDA Civic, 3-dr, 5-spd, a/c, stereo, 111K mi., engine replaced, new tires, $2490. Ulli, X5347, 601-6541

'87 TOYOTA pickup, 4x4, stereo, a/c, new clutch, $5K/b.o. X5415

'88 VOLVO 760 turbo wgn, leather, sunroof, loaded, 139K mi., 1 yr. warranty on engine, $9500. Mari, X5932

'90 HONDA Accord EX, 4-dr, a/t, 75K mi., burgundy/gray, exc. cond., $10.5K. X6221, 938-5100 (eve.)

'90 SUBARU Legacy wgn, 81K mi., exc. cond., 4-dr, a/t, a/c, AM/FM, leaving, must sell, $6K. X4464, 549-9077

PARTS for Porsche Carrera, new 2 pc. bra, Colgan, $50; new Yetl snow chains, ski rack, $50. 376-3241

CAR/VANPOOL

CARPOOL, rider wanted, from Vacaville-Fairfield area to LBNL, Mon.-Fri., work hrs. 7 a.m.-3:30 p.m., arrive LBNL approx. 6:45 a.m. Mark, X4671

TICKETS

KABUKI(GRAND KABUKI), Sat., 9/14, 8 p.m., 1 seat, H 101, Zellerbach Hall (UCB), $29. Takahito, X4823, X4213, 528-0745

SF OPERA, Sat. eve., 9/14, Hamlet, Sec. F pair (Opera House front balcony equivalent), Orpheum Theater, $84/pr. P. Concus, 526-3519

WANTED

AUTOMOBILE, '91-'94 Jeep Cherokee, to buy. Mats, X5039, 526-7844

BABY-SITTER for 2 yr. old boy. Elisabetta, 841-8763

GOLF CLUBS, in gd cond. Tim, X5304

INFANTS/TODDLERS to share child care in pvt central Berkeley home, 8 a.m.-6 p.m., Mon.-Thurs., p/t negot. Geri, 848-2321

MISCELLANEOUS

BICYCLES, Schwinn Starlet, perfect for K-1 girl, 12" frame, banana seat, sparkle purple paint, white fenders, spotless, brand-new cond., $75; Huffy Expedition, woman's/girl's mountain bike, 18"frame, 10-spds, pink-blue-silver paint, great cond., $60. Carol, X4812

CAMERA BODY, under warranty, Canon Elan, auto focus, 35mm, Canon F1.8 50mm lens, both in exc. cond., $350. 841-6285

CHAIR, $20; upholstered rocking chair, $50; dinner table, $20. Rose, X7554, 236-6815

COLOR PRINTER, Panasonic Impact Dot Matrix, model KX-P2124, 24-pin, 7 colors, 12 fonts, friction or traction paper feed, $150/b.o.; high chair, Fisher-Price, great cond., $30; table desk, Queen Anne style, cherry finish on oak, w/captain's chair, $200/b.o. Auben, X4796, 245-0343

COMPUTER, Pentium, 60 MHz, 16 MB RAM, 540 HDD, CD ROM, $600. Paul, X7311, 848-7400 (eve.)

COMPUTER ACCESSORIES, Sony, SrS - D2KPC 20 watt stereo amplifier (sm.), subwoofer & 2 full range spkrs, use w/computer or CD, tape, $100. Martin, X5738, 540-0214

DISHWASHER, full sz., portable Kitchen Aid, solid wood chopping block, 3 yrs. old, $500; Nishiki MTBs, 21.5" Deore XT/XTR, $500; 22" commuter, $150; Windsurfer, Hy Fly, 11.5' w/sails(2), mast, boom & hardware $600. Rick, X7341, 234-0451

ELECTRIC BED, head or feet can be raised independently, $1K/b.o. Marie, X4317

EXERCISE MACHINE, Lifestyler Cardiofit plus, paid $260, take $120; 5-pack of unopened 4 to 6 hr video tapes, $10; blk steel frame futon & pad $90; blk vinyl couch, $90; blk 6' floor halogen lamp, $10; director's chair w/grn seat & back, $18; blk dining room set for two, 2 chairs & table, $75, all items are 6 mo. old. Kris, X5571

FURNITURE, American-made, Danish-style dining rm set, table w/3 leaves, 6 chairs, buffet, hutch, $800; antique Belgian oak bdrm set, "art deco" style from 1930s, bed, armoire, dresser, night stand, $2500; chest bed w/mattress, $60. 527-6220

FUTON MATTRESS, dbl, 3 wks old, $50. Viki, 549-1876 (after 5:30 p.m.)

GARAGE SALE, bookshelf, microwave oven, lamps, coffee table & more, 8/17, 1:30-4 p.m., 629 Carmel Ave., Albany

GARAGE SALE, Sat., 8/17, 10 a.m.-5 p.m., 1658 Oxford, btwn Cedar & Virginia

LAMPSHADES (4), lg., $5 ea. Kathy, X4931, 855-9135

MACINTOSH PowerBook Duo 250 12/200, incl. 14.4 modem, dock, keyboard & mouse, $1100. Bill, X6693, 601-1404

MOVING SALE, metal bunk-bed, white (can be separated into single beds), $150; 2 sturdy oak chairs, $30 ea.; bike child seat, Fisher-Price, $30; sm. drop-lid chest, $30; 2-slice toaster, wafer/pancake maker, elec. slow cooker, $7 ea. X4125, 528-7876

PERSONAL SAFETY ALARM, Quorum, products & sales materials, 2 yrs. old, worth $1500, make offer. 704-8236

ROLL-TOP DESK, solid oak, paid $300; 2-drawer file cabinet, solid oak, paid $150, $200 for both. Kelly, X4570, 634-5364

WATER FILTERS, NSA, sink installation. Marek, X5029, 582-5867

HOUSING

BERKELEY, Northside, Rose & Walnut, furn. 1-bdrm apt, util + local phone, cleaning, avail. 10/1-21, $350/wk, $850/3 wks. 549-1876

BERKELEY, Northside, furn. rm in 4-bdrm house, 5 blks to UCB, 2 visiting scholars live here, bay & SF view, no smoking/pets, $500/mo. + util. 548-1287

BERKELEY, on Grizzly Peak, 1-bdrm in-law apt in house, bay view, flower garden, nr bus, $450/mo. Kevin, X6357

BERKELEY, Elmwood, furn. 1-bdrm+ apt, sunny, walk to UCB & public trans., lg. garden terrace overlooking Berkeley Hills, split-level w/lg. windows, linen, dishes, TV, hi-fi, VCR, microwave, for non-smoker, avail. 8/20, min. 10 mo., $885/mo. 843-6325 (msg.)

BERKELEY, unfurn. 2-bdrm, 1-bth house, converted garage suitable for study, sm. enclosed yd, 4 blks from 4th St. dist., non-smokers, avail. 8/19, $975/mo. 528-0172

NO. BERKELEY, lg., furn. 4-bdrm+, bay view, nr bus, avail. 8/25 - 6/15/97, $1900/mo. 528-1814, 525-7346

SO. BERKELEY, furn. 2-bdrm. apt, split-level, newly refurbished, skylights, 10 min. walk to UCB, nr bus & shops, all utils. incl., 4-unit brn shingle, $1100/mo. Kathy, 482-1777

SO. BERKELEY, 1-bdrm apt, 10 min. walk to UCB, utils. incl., garden, $575/mo. Kathy, 548-0120

CASTRO VALLEY, rm in 3-bdrm house, laundry & kitchen privs., $400/mo. Marek, X5029, 582-5867

OAKLAND HILLS, recently built 3-bdrm, 2.5-bth house, bay views, master bdrm suite, lg. living rm w/frpl, family rm & kitchen w/hardwd flrs, deck, laundry, 2-car garage, convenient loc. 15 min. drive from LBNL/UCB, $1695/mo. 490-3073

WANTED: former LBNL visiting scholar, non smoker, needs a place to live Oct. '96-May '97, prefer Berkeley. C.T.C.Heijning@cpedu.rug.nl

WANTED: academic couple from Toronto want house/cottage Jan.-March '97, non-smokers, able to care for garden. jbaker@venus.yorku.ca

WANTED: accommodation in Sept. for visiting academic from New Zealand, requires a studio/1-bdrm apt for 1 mo. from 9/2, will house sit or rent. 011-64-4-802-6221, michael.donn@vuw.ac.nz

REAL ESTATE

BERKELEY, at Oregon & Fulton, 2-bdrm, 1-1/2 bth townhouse/condo, 1 mi. walking distance to UCB, pvt yd, $119K. 235-3983

MORAGA, 2-bdrm, 2-bth townhouse, 2-story, vaulted beam ceilings, den, 1600 sq. ft., new roof, carpets, kitchen, many upgrades, 1 blk from pool, pvt., at cul-de-sac w/500 acre backyd, cyn & Mt. Diablo views, 1 blk from hiking trails, workshop, 2-car garage, redwood deck, lg. front patio & side yd, new fencing, 1 mi. from schools, trans. & shopping, 12 mi. non-fwy commute to LBNL, incl. appliances, possible OWC, avail. ~Nov. 376-3241

VACATION

BAHAMAS, Taino Beach Resort, 1-bdrm condo, slps 4, every amenity, on beach, pool, tennis, 60 days adv. notice, $500/wk. X6005

HIGH SIERRAS, 4-bdrm cabin, washer, dryer, deck, frpl, hiking, fishing, swimming, canoeing, 4 hr. from Berkeley, 1 hr. from Truckee, on Hwy. 49, for people who will take gd care of our vacation home, wk/wkends. Jane, 849-4096

MENDOCINO COUNTY, 2-bdrm, 2-bth country home on Greenwood Ridge nr Elk, set on 24 acres of Redwood forest, panoramic views overlooking the Anderson Valley. Rose, 849-1726

LOST & FOUND

LOST: bicycle lock, black kryptonite, u-shaped. David, (619) 327-5757

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Flea Market ad policy

Due to the large volume of ads received each week, ads are accepted only from LBNL employees, retirees, and on-site DOE personnel. No other ads will be accepted. We encourage past contributors to the Flea Market to use other local services, such as LBNL's online housing listing (call X6198 for information), and the UC Housing Office.

Please note also:

============

Currents/The View and the Communications Department Staff

Published once a month by the Communications Department for the employees and retirees of Berkeley Lab.

Reid Edwards, Public Affairs Department head
Ron Kolb, Communications Department head

EDITOR
Pamela Patterson, 486-4045, pjpatterson@lbl.gov
Associate editor
Lyn Hunter, 486-4698, lhunter@lbl.gov

STAFF WRITERS
Dan Krotz, 486-4019
Paul Preuss, 486-6249
Lynn Yarris, 486-5375

CONTRIBUTING WRITERS
Ucilia Wang, 495-2402
Allan Chen, 486-4210
David Gilbert, (925) 296-5643

DESIGN
Caitlin Youngquist, 486-4020
Creative Services Office

Berkeley Lab
Communications Department
MS 65, One Cyclotron Road, Berkeley CA 94720
(510) 486-5771
Fax: (510) 486-6641

Berkeley Lab is managed by the University of California for the U.S. Department of Energy.

Flea Market is now online at www.lbl.gov/fleamarket

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